{"id":"W2985072184","doi":"10.1182/blood-2019-129357","title":"Bortezomib-Based Induction, Augmented Conditioning with Busulfan and Melphalan + ASCT and Lenalidomide Maintenance for Newly Diagnosed Multiple Myeloma: Long-Term Results of the National Canadian Mcrn-001 Study","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; London Health Sciences Centre; Hôpital Maisonneuve-Rosemont; Université de Montréal; Leukemia & Lymphoma Society of Canada; University of British Columbia; Saint John Regional Hospital; University of Ottawa; McGill University Health Centre; University of Alberta; Queen Elizabeth II Health Sciences Centre; Dalhousie University; Princess Margaret Cancer Centre","funders":"","keywords":"Lenalidomide; Melphalan; Multiple myeloma; Bortezomib; Busulfan; Medicine; Maintenance therapy; Oncology; Internal medicine; Hematopoietic stem cell transplantation; Transplantation; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002913808,0.0009217959,0.001447104,0.0002809806,0.0008186927,0.001013611,0.001127573,0.0007739475,0.001193537],"category_scores_gemma":[0.001040741,0.0003708383,0.001089415,0.0006628052,0.0008665518,0.0004726965,0.0004889256,0.001945271,0.0003044426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006967322,"about_ca_system_score_gemma":0.01061317,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.1970403,"about_ca_topic_score_gemma":0.3906489,"domain_scores_codex":[0.9990571,0.000276089,0.00004614271,0.0001203313,0.0002628938,0.0002375406],"domain_scores_gemma":[0.9985107,0.00008769797,0.0002247572,0.000133656,0.0001481428,0.0008950748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7000028,0.04095735,0.1089484,0.0007343038,0.005463819,0.0003631824,0.000569952,0.003030681,0.01466322,0.0002962856,0.0115716,0.1133984],"study_design_scores_gemma":[0.1886717,0.2614217,0.5199155,0.0001626172,0.004449129,0.0005443332,0.0002582289,0.001566318,0.003994603,0.0002604067,0.01862799,0.0001276243],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905348,0.00277477,0.0001878316,0.0005400675,0.00008935227,0.0009552698,0.002259588,0.00002862228,0.002629526],"genre_scores_gemma":[0.9890514,0.001406055,0.0005625722,0.0008117381,0.000130676,0.0004965045,0.005027158,0.00001429835,0.002499515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8029597,"threshold_uncertainty_score":0.3917868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02046326695381915,"score_gpt":0.2765029848338957,"score_spread":0.2560397178800766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}