{"id":"W2985110338","doi":"10.1097/qad.0000000000002323","title":"Pre-exposure prophylaxis differentially alters circulating and mucosal immune cell activation in herpes simplex virus type 2 seropositive women","year":2019,"lang":"en","type":"article","venue":"AIDS","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Herpes simplex virus; Immunology; Immune system; Subclinical infection; Pre-exposure prophylaxis; CD8; Immunity; Medicine; Discontinuation; Viral shedding; Virus; Innate immune system; Virology; Biology; Human immunodeficiency virus (HIV); Internal medicine; Men who have sex with men; Syphilis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001397213,0.0001431883,0.0001891898,0.0001809789,0.0001459753,0.0002989173,0.00007463675,0.0002023794,0.001611376],"category_scores_gemma":[0.0005389628,0.00009835417,0.00008051514,0.0001472383,0.0001143695,0.0001339677,0.0001054691,0.0001944451,0.0001886281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008813534,"about_ca_system_score_gemma":0.000111027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003487468,"about_ca_topic_score_gemma":0.0005972995,"domain_scores_codex":[0.9999014,0.00003361922,0.000004996718,0.00001834023,0.00001532414,0.00002619756],"domain_scores_gemma":[0.9998877,0.00003637427,0.00003317573,0.000008027471,0.00001139097,0.00002329383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007419531,0.0007784706,0.7718533,0.0002411046,0.00007443439,0.001968259,0.00149944,0.0001460427,0.1587017,0.0001048557,0.0004164719,0.05679642],"study_design_scores_gemma":[0.00001861671,0.002317244,0.9900017,0.00002356661,0.00003371524,0.001197137,0.0005593978,0.0001237281,0.004712357,0.0000405708,0.0009668104,0.000005109188],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989958,0.0004709687,0.000043376,0.00001961338,0.000005167607,0.000008446193,0.00004446735,0.000002041104,0.0004101743],"genre_scores_gemma":[0.9992493,0.0002351405,0.00006997371,0.00003253037,0.000008598934,0.00001265761,0.00005264879,0.000001011559,0.0003382216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001611376,"threshold_uncertainty_score":0.005390584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006853077587373857,"score_gpt":0.2467656611230835,"score_spread":0.2399125835357097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}