{"id":"W2985130805","doi":"10.1093/neuonc/noz175.994","title":"STEM-21. INVESTIGATING DOT1L AS AN EPIGENETIC VULNERABILITY IN BRAIN TUMOR STEM CELLS","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Calgary; University of Toronto; SickKids Foundation; Ontario Brain Institute","funders":"","keywords":"Stem cell; Biology; Cancer research; Epigenetics; Neural stem cell; Embryonic stem cell; Methyltransferase; Cancer stem cell; Cell biology; Genetics; Methylation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001429557,0.0002516504,0.0002749117,0.0002923264,0.0001774163,0.000363382,0.0001721782,0.0003621746,0.002211736],"category_scores_gemma":[0.00008579309,0.0001139767,0.0002445369,0.0002069378,0.0001975537,0.0001682374,0.0002162601,0.000357243,0.0006051118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004144368,"about_ca_system_score_gemma":0.0002411013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000978036,"about_ca_topic_score_gemma":0.001330501,"domain_scores_codex":[0.9998894,0.000008799416,0.00000968388,0.00003379974,0.00003993136,0.00001846838],"domain_scores_gemma":[0.9999238,0.000009851006,0.00002667845,0.000006581275,0.00001372432,0.00001934263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005613518,0.00001690057,0.0004939734,0.00006340213,0.000006109794,0.00007094116,0.00001701273,0.0000823508,0.9965476,0.0001578,0.00007457065,0.002413159],"study_design_scores_gemma":[0.00000950059,0.0002453899,0.007443028,0.000007356709,0.00002296716,0.0002996661,0.0000398245,0.0009612846,0.984903,0.00007008466,0.005993919,0.000003906813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825852,0.003094021,0.005790439,0.0002446331,0.00006630285,0.0001236022,0.003137534,0.0002559969,0.004702209],"genre_scores_gemma":[0.9876304,0.001118314,0.001981194,0.0001110608,0.000005407849,0.00006512757,0.002813285,0.00002624958,0.006248907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002211736,"threshold_uncertainty_score":0.007399023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02122578722057692,"score_gpt":0.2956719084153164,"score_spread":0.2744461211947395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}