{"id":"W2985136181","doi":"10.1016/j.nicl.2019.102077","title":"White matter hyperintensities in progranulin-associated frontotemporal dementia: A longitudinal GENFI study","year":2019,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Toronto; Occupational Cancer Research Centre; Health Sciences Centre; McGill University Health Centre; Sunnybrook Health Science Centre; Université Laval","funders":"Centre For Medical Engineering, King’s College London; NIHR Cambridge Biomedical Research Centre; UCL Queen Square Institute of Neurology,University College London; Seventh Framework Programme; Medical Research Council; UCLH Biomedical Research Centre; Engineering and Physical Sciences Research Council; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Centro Hospitalar Universitário do Porto; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; University College London Hospitals NHS Foundation Trust; Università degli Studi di Brescia; Alzheimer's Society; Ministero della Salute; Deutsches Zentrum für Neurodegenerative Erkrankungen; Ente Cassa di Risparmio di Firenze; Alzheimer’s Research UK; Universität Ulm; Ministry of Health; Toronto Rehabilitation Institute; University of Manchester; University of Toronto; Wellcome Trust; University College London; FP7 Information and Communication Technologies; Wolfson Foundation; McGill University; McGill University Health Centre; Brain Research Trust; Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta; Ontario Research Foundation; National Institute for Health and Care Research; ZonMw; Karolinska Institutet; Alzheimer Nederland; Sunnybrook Research Institute; Università degli Studi di Firenze; University Health Network; Manchester Biomedical Research Centre; Mayo Clinic","keywords":"Frontotemporal dementia; Hyperintensity; Grey matter; White matter; Dementia; Proband; Psychology; Neurodegeneration; Biomarker; Pathology; Neuroscience; Audiology; Medicine; Oncology; Cardiology; Mutation; Magnetic resonance imaging; Disease; Genetics; Biology; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001229165,0.0002616174,0.0008406589,0.0001394686,0.00004762204,0.00007705005,0.0002382075,0.0001821758,0.002222591],"category_scores_gemma":[0.0003357062,0.0002140114,0.0002586388,0.0002806239,0.0001875595,0.0001672479,0.0003008323,0.001141211,0.00183127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008793317,"about_ca_system_score_gemma":0.0001100893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000202637,"about_ca_topic_score_gemma":0.0001605656,"domain_scores_codex":[0.9962146,0.0005453415,0.001035051,0.0008591654,0.0007026892,0.0006431966],"domain_scores_gemma":[0.9985321,0.000180895,0.0001415091,0.0006772543,0.0002185304,0.0002497841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008283784,0.002405916,0.9932071,0.00003026331,0.0001447865,0.0008512652,0.0001725103,0.000002144371,0.0002066786,7.963906e-7,0.001774956,0.0003752261],"study_design_scores_gemma":[0.00624045,0.002624607,0.9898571,0.00007024162,0.00009214324,0.00002897648,0.0001754259,0.0004888233,0.000002480153,0.00000879716,0.0002271129,0.0001837858],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936852,0.0000466581,0.000005361405,0.002389252,0.0004030219,0.001816449,0.000006014431,0.00008898295,0.001559067],"genre_scores_gemma":[0.9954324,0.0000174446,0.0002248021,0.001136837,0.0001716064,0.00005245755,0.0000195946,0.00005858731,0.002886229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005412071,"threshold_uncertainty_score":0.9989459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0819731924341804,"score_gpt":0.3849631012099343,"score_spread":0.3029899087757539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}