{"id":"W2985155561","doi":"10.1016/j.cell.2019.10.026","title":"Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing","year":2019,"lang":"en","type":"article","venue":"Cell","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":303,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; Canada's Michael Smith Genome Sciences Centre; Genome British Columbia; University of British Columbia","funders":"National Cancer Institute; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Terry Fox Research Institute; Cancer Research UK","keywords":"Biology; Genome; Genetics; Computational biology; Single-cell analysis; Origin of replication; clone (Java method); Somatic evolution in cancer; Cell; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000721645,0.00009030384,0.00007855022,0.00001605763,0.0000386267,0.00003127071,0.00006488667,0.00007445012,0.00001993115],"category_scores_gemma":[0.000009065935,0.00009849767,0.00002829571,0.0000277042,0.00002259297,0.000002654781,0.00005364915,0.00003703332,0.00002522299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003930579,"about_ca_system_score_gemma":0.00003628183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002059724,"about_ca_topic_score_gemma":0.000006767326,"domain_scores_codex":[0.9993688,0.00001366022,0.0001224908,0.0003117009,0.00004852892,0.0001347549],"domain_scores_gemma":[0.9995511,0.00002065936,0.00006466489,0.0002650129,0.00003980078,0.00005874625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002537196,0.0000362722,0.0008501905,0.00002384025,0.000004277887,4.080928e-7,0.00002325024,0.00009710727,0.9977652,0.000007746443,0.0009802351,0.0001861464],"study_design_scores_gemma":[0.0005235682,0.0002289787,0.0006594012,0.000004166955,0.00001199398,0.000004608767,0.00002795096,0.0002524199,0.974956,0.0001030853,0.02308129,0.0001464749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948497,0.001664082,0.0008207214,0.00007197178,0.00006752541,0.0001455948,0.00006492232,0.000007595161,0.002307826],"genre_scores_gemma":[0.9966267,0.0004312326,0.0009118147,0.0003420515,0.0000714142,0.000007878525,0.0009506164,0.00001683699,0.000641444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02280909,"threshold_uncertainty_score":0.4016618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006470382682052017,"score_gpt":0.2128284865119169,"score_spread":0.2063581038298649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}