{"id":"W2985155561","doi":"10.1016/j.cell.2019.10.026","title":"Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing","year":2019,"lang":"en","type":"article","venue":"Cell","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":303,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; Canada's Michael Smith Genome Sciences Centre; Genome British Columbia; University of British Columbia","funders":"National Cancer Institute; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Terry Fox Research Institute; Cancer Research UK","keywords":"Biology; Genome; Genetics; Computational biology; Single-cell analysis; Origin of replication; clone (Java method); Somatic evolution in cancer; Cell; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004428884,0.0002089076,0.0003217459,0.0005091102,0.0003416333,0.0009672836,0.00036762,0.000429936,0.001365023],"category_scores_gemma":[0.001816882,0.0002952066,0.0002808186,0.0004786911,0.0006881607,0.000816162,0.0004700728,0.0006941351,0.0002537167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009151201,"about_ca_system_score_gemma":0.0004210289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001382062,"about_ca_topic_score_gemma":0.002051061,"domain_scores_codex":[0.9997595,0.00003774979,0.00001335499,0.00008881805,0.00007059541,0.00003006558],"domain_scores_gemma":[0.9991411,0.0003547453,0.0001174135,0.0001685132,0.00013199,0.00008617627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001857067,0.00005331146,0.005072223,0.00006207555,0.0000243955,0.0001433787,0.0002424066,0.03099361,0.9005913,0.04638595,0.0005458735,0.01569977],"study_design_scores_gemma":[0.00002053399,0.0001144625,0.01655377,0.00001815107,0.00002804968,0.0002237784,0.0001796824,0.4834511,0.4615324,0.03271696,0.005107232,0.00005380596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7577525,0.0004158927,0.2353832,0.0001324389,0.00004587785,0.00006309733,0.0005786094,0.0007560406,0.00487224],"genre_scores_gemma":[0.9487642,0.000145217,0.04891437,0.00006365121,0.00001001954,0.00007881629,0.0005035348,0.000153327,0.001366888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001382062,"threshold_uncertainty_score":0.006639719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006470382682052017,"score_gpt":0.2128284865119169,"score_spread":0.2063581038298649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}