{"id":"W2985195500","doi":"10.1016/j.jid.2019.09.022","title":"Allele-Specific Small Interfering RNA Corrects Aberrant Cellular Phenotype in Keratitis-Ichthyosis-Deafness Syndrome Keratinocytes","year":2019,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"National Eye Institute; National Institutes of Health; Wellcome Trust","keywords":"Ichthyosis; Phenotype; Allele; Keratitis; Genetics; Biology; Medicine; Dermatology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003122048,0.0004096211,0.0003282793,0.0003812503,0.0002998741,0.000479938,0.0003861289,0.0006405468,0.001885962],"category_scores_gemma":[0.0002816066,0.0002561422,0.0002703716,0.0001752785,0.0003840375,0.0002026694,0.0002585521,0.0008625421,0.0006599529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000293576,"about_ca_system_score_gemma":0.0004108395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008739354,"about_ca_topic_score_gemma":0.001494415,"domain_scores_codex":[0.9995992,0.00006097619,0.00007617395,0.00007159655,0.0001282779,0.00006385797],"domain_scores_gemma":[0.9996756,0.0001287029,0.00005630639,0.00006329297,0.00002810018,0.00004804443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000350894,0.000023503,0.00005077229,0.00001977028,0.000004401043,0.0001727751,0.00001741526,0.00009615078,0.9986799,0.0002023672,0.00004781009,0.0006499633],"study_design_scores_gemma":[0.00003560989,0.0001209332,0.001446036,0.0000058734,0.00002434579,0.0005738681,0.00005477261,0.001814816,0.9932258,0.00008903878,0.002602518,0.000006306829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986819,0.0008100187,0.007826984,0.0003472297,0.0003498039,0.00007543866,0.0005993244,0.0004773271,0.002694834],"genre_scores_gemma":[0.9929318,0.0003917986,0.002789752,0.00006452989,0.00001528751,0.00003299978,0.0002660555,0.00008041911,0.003427374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001885962,"threshold_uncertainty_score":0.006309152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0162701778824792,"score_gpt":0.2161642598045145,"score_spread":0.1998940819220353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}