{"id":"W2985248532","doi":"10.1182/blood-2019-129805","title":"Safety, Efficacy, and PK of the BCL2 Inhibitor Venetoclax in Combination with Chemotherapy in Pediatric and Young Adult Patients with Relapsed/Refractory Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia: Phase 1 Study","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Venetoclax; Ven; Internal medicine; Population; Tumor lysis syndrome; Refractory (planetary science); Gastroenterology; Oncology; Chemotherapy; Leukemia; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001298973,0.0007685353,0.001323482,0.0002776098,0.0002696169,0.0007269471,0.0005933653,0.0005666175,0.001628784],"category_scores_gemma":[0.0008603455,0.0003734046,0.0008177821,0.0004191174,0.0004951764,0.0005452234,0.0002582587,0.001714395,0.0003484068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009777509,"about_ca_system_score_gemma":0.001578415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006920439,"about_ca_topic_score_gemma":0.001774215,"domain_scores_codex":[0.9995489,0.0002451936,0.00002430247,0.00007450732,0.00004913037,0.00005805232],"domain_scores_gemma":[0.9992884,0.0001091846,0.0002494672,0.00005771491,0.00003737327,0.000257853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5948635,0.09475705,0.05757803,0.001099312,0.002545518,0.0005910905,0.0006868964,0.004692456,0.05261623,0.0004448702,0.003957924,0.1861671],"study_design_scores_gemma":[0.2125136,0.7143947,0.05788492,0.0000822136,0.0009741395,0.001048636,0.0001157372,0.001684766,0.005541102,0.0002165397,0.005507982,0.00003575147],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966275,0.001446495,0.000278394,0.00009347085,0.00001602921,0.0006021577,0.0004741649,0.00002094247,0.0004408245],"genre_scores_gemma":[0.9933698,0.00197497,0.001212965,0.0002921013,0.00006970736,0.001244357,0.001183907,0.00001210808,0.000639963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001628784,"threshold_uncertainty_score":0.007094145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004360733275188402,"score_gpt":0.2347910314371434,"score_spread":0.230430298161955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}