{"id":"W2985298190","doi":"10.1186/s12974-019-1622-1","title":"Nav1.6 promotes inflammation and neuronal degeneration in a mouse model of multiple sclerosis","year":2019,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Al Jouf University; Dalhousie University; Nova Scotia Health Research Foundation; Dalhousie Medical Research Foundation","keywords":"Experimental autoimmune encephalomyelitis; Multiple sclerosis; Sodium channel; Inflammation; Gliosis; Retinal ganglion cell; Retinal degeneration; Pathology; Retina; Microglia; Optic nerve; Biology; Neuroscience; Medicine; Immunology; Chemistry; Sodium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004721398,0.0001189988,0.00033892,0.0004259641,0.00003056929,0.00002262053,0.00006435931,0.00005949413,0.000009461849],"category_scores_gemma":[0.0009636845,0.0001017015,0.00007495184,0.0001650336,0.0000428157,0.0005322638,0.00004489959,0.0002415681,0.000003313712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006191699,"about_ca_system_score_gemma":0.0001024428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007711697,"about_ca_topic_score_gemma":0.00002878838,"domain_scores_codex":[0.9982972,0.00009771759,0.0007563129,0.0001381357,0.0005614155,0.0001491889],"domain_scores_gemma":[0.9986951,0.0001568313,0.0005046898,0.0001402725,0.0004250847,0.00007806771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00045772,0.00006168126,0.0270566,0.000203808,0.00001542936,0.000001708191,0.0005108886,0.01097669,0.9524527,0.00003209583,0.00001289989,0.008217765],"study_design_scores_gemma":[0.002377518,0.0003780395,0.1819775,0.0001876394,0.0000160178,0.0000135281,0.00004509098,0.2492907,0.5656115,0.00003678445,0.000006780931,0.00005886391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982925,0.00003514954,0.0002164782,0.0007944474,0.00004863795,0.0005327235,0.000005786429,0.000008649798,0.00006563745],"genre_scores_gemma":[0.99731,0.0003583378,0.0021389,0.00000832695,0.00009136547,0.000005785213,0.000006004818,0.00001622414,0.00006504852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3868412,"threshold_uncertainty_score":0.4147269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06879529852818517,"score_gpt":0.2797843477627466,"score_spread":0.2109890492345614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}