{"id":"W2985424883","doi":"10.1182/blood-2019-124934","title":"Initial Characterization and Toxicology of an Nmt Inhibitor in Development for Hematologic Malignancies","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Myristoylation; Dasatinib; Kinase; LYN; Cancer research; Proto-oncogene tyrosine-protein kinase Src; Ibrutinib; Apoptosis; Chemistry; Biology; Cell growth; Leukemia; Pharmacology; Chronic lymphocytic leukemia; Myeloid leukemia; Biochemistry; Immunology; Phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001740258,0.0003613537,0.0002401386,0.0003449087,0.0002063475,0.0003203475,0.0002743961,0.0002924421,0.001715802],"category_scores_gemma":[0.0002097817,0.0001452419,0.0002173044,0.0002648704,0.0001250499,0.0002073545,0.0001478516,0.0003975713,0.000450796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000439169,"about_ca_system_score_gemma":0.0003771981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001032652,"about_ca_topic_score_gemma":0.002138185,"domain_scores_codex":[0.9998703,0.00001997594,0.000007145023,0.00002179389,0.00005658233,0.00002409485],"domain_scores_gemma":[0.9999272,0.00001062143,0.00001630932,0.000006222644,0.00002176438,0.00001779559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003448341,0.0002661364,0.0006446232,0.0001610243,0.00002120145,0.0001681578,0.00003323412,0.001038922,0.9755347,0.000253724,0.0005419357,0.02099164],"study_design_scores_gemma":[0.000118713,0.004678987,0.003053807,0.00002663858,0.0000554714,0.0008141875,0.00002387566,0.001608616,0.9644805,0.00007058455,0.02505825,0.00001034741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9499488,0.01469081,0.01294133,0.000364634,0.0000637564,0.001185041,0.003313684,0.000279198,0.01721269],"genre_scores_gemma":[0.9641008,0.0098728,0.008400835,0.0001899154,0.00002858363,0.000333774,0.004067775,0.00005719128,0.01294828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001715802,"threshold_uncertainty_score":0.005739927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01748137217340298,"score_gpt":0.2693090047003008,"score_spread":0.2518276325268978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}