{"id":"W2985427120","doi":"10.1139/bcb-2019-0156","title":"Nicotine-upregulated miR-30a arrests cell cycle in G1 phase by directly targeting CCNE2 in human periodontal ligament cells","year":2019,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Downregulation and upregulation; Periodontal fiber; Nicotine; Cell biology; Cell growth; Chemistry; Cell culture; Cell cycle; In vitro; Cell; Molecular biology; Biology; Biochemistry; Dentistry; Medicine; Neuroscience","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001395434,0.0002105682,0.0003187961,0.0002434913,0.000227684,0.0003104119,0.0001288886,0.0002069005,0.001002811],"category_scores_gemma":[0.0001587721,0.0001419186,0.0003603272,0.0001505539,0.0001766119,0.0001584253,0.0001349589,0.0004313232,0.0004221324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003741038,"about_ca_system_score_gemma":0.0004159799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001643313,"about_ca_topic_score_gemma":0.002592143,"domain_scores_codex":[0.9998265,0.00002319804,0.00002185316,0.00004062899,0.00005985799,0.00002804969],"domain_scores_gemma":[0.9999431,0.00001487457,0.00001111854,0.000008244324,0.00001138907,0.00001115323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001064406,0.00003217942,0.0001962566,0.00004272173,0.00000412119,0.00003087687,0.0000203467,0.00004224974,0.9981245,0.00006097736,0.00005669703,0.001282516],"study_design_scores_gemma":[0.00002260866,0.0002559265,0.00745557,0.000006737836,0.00001737267,0.0001787947,0.00002941103,0.001394946,0.9858968,0.00004409766,0.00469149,0.000006316719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849795,0.007184538,0.003292517,0.0001988353,0.0001045009,0.00009112419,0.0007741712,0.0001371319,0.003237729],"genre_scores_gemma":[0.9912311,0.00171599,0.003561048,0.000121994,0.00001330967,0.00009494378,0.0007849981,0.00002022125,0.002456245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001643313,"threshold_uncertainty_score":0.003354788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00307048908600627,"score_gpt":0.2277507527882835,"score_spread":0.2246802637022772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}