{"id":"W2985453509","doi":"10.3389/fnagi.2019.00302","title":"Diabetes, a Contemporary Risk for Parkinson’s Disease: Epidemiological and Cellular Evidences","year":2019,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada; Regione Autonoma della Sardegna; Commonwealth Scientific and Industrial Research Organisation","keywords":"Neurodegeneration; Substantia nigra; Dopaminergic; Parkinson's disease; Diabetes mellitus; Neuroscience; Oxidative stress; Disease; Pathogenesis; Medicine; Glycation; Nigrostriatal pathway; Polyol pathway; Biology; Bioinformatics; Internal medicine; Endocrinology; Dopamine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005502332,0.0001804284,0.000386429,0.0001347055,0.0001083115,0.00003538794,0.0001464388,0.00004486978,0.000004590125],"category_scores_gemma":[0.0006572523,0.0001387261,0.00008990333,0.0002007958,0.000170169,0.0001813885,0.00006376976,0.000134664,0.000003278026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004632282,"about_ca_system_score_gemma":0.0001019154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001175477,"about_ca_topic_score_gemma":3.45064e-7,"domain_scores_codex":[0.9983361,0.0001232181,0.000222437,0.0007178442,0.0002146238,0.00038577],"domain_scores_gemma":[0.9991313,0.000153361,0.0001143172,0.0002659384,0.00001978979,0.0003152444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001009304,0.00008765175,0.995356,0.00007622592,0.000005942106,0.00006127427,0.00002277653,0.00001387781,0.0008793255,0.00004965588,0.001257493,0.002088887],"study_design_scores_gemma":[0.001386741,0.000299174,0.9167461,0.0002067312,0.0000536371,0.000002055408,0.00004578822,0.03573941,0.0004580642,0.002196158,0.04268473,0.0001814029],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840451,0.009003467,0.004181778,0.0006437362,0.001038749,0.0009109231,0.00004780063,0.0000530791,0.00007532568],"genre_scores_gemma":[0.9938037,0.0004493086,0.004047662,0.001223202,0.00003617225,0.00009560592,0.000008442206,0.00001310664,0.0003227876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07860985,"threshold_uncertainty_score":0.5657088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03378858629099905,"score_gpt":0.2779642429842009,"score_spread":0.2441756566932018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}