{"id":"W2985480179","doi":"10.1182/blood-2019-129845","title":"Landmark Response and Survival Analyses from 206 AML Patients Treated with Guadecitabine in a Phase 2 Study Demonstrate the Importance of Adequate Treatment Duration to Maximize Response and Survival Benefit. Survival Benefit Not Restricted to Patients with Objective Response","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Survival analysis; Cell survival; Overall survival; Medicine; Internal medicine; Oncology; Biology; Apoptosis; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001356356,0.0003531934,0.0007240328,0.0003016864,0.0002435355,0.000294377,0.0002161497,0.000393476,0.001462471],"category_scores_gemma":[0.001448216,0.0001241511,0.0007464361,0.0002462657,0.0002691988,0.0003048562,0.0003112001,0.0008163977,0.0002342821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003892143,"about_ca_system_score_gemma":0.0003247939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002901066,"about_ca_topic_score_gemma":0.0005607717,"domain_scores_codex":[0.9995215,0.0002288481,0.00004100799,0.00006933545,0.00008690271,0.00005242371],"domain_scores_gemma":[0.9986896,0.000445909,0.0003479478,0.0002026081,0.0000830752,0.0002308324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3457254,0.01450234,0.3400596,0.0004937128,0.001312761,0.001106859,0.0006929383,0.01455967,0.1164799,0.000396202,0.003639841,0.1610308],"study_design_scores_gemma":[0.02015567,0.25936,0.6620869,0.00002989717,0.0007702775,0.002390496,0.0001592954,0.008310732,0.03932875,0.0004596876,0.006846582,0.0001016954],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982613,0.0001540707,0.0005857177,0.00003180414,0.000006597011,0.0001193933,0.0004826053,0.00002509301,0.0003335324],"genre_scores_gemma":[0.994813,0.00007796179,0.001795041,0.00008066756,0.00002588386,0.0002758187,0.002333994,0.00001365139,0.0005840848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001462471,"threshold_uncertainty_score":0.00717324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01624265700697788,"score_gpt":0.290430284858995,"score_spread":0.2741876278520172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}