{"id":"W2985519791","doi":"10.1111/aos.14281","title":"A distinct retinal pigment epithelial cell autofluorescence pattern in choroideremia predicts early involvement of overlying photoreceptors","year":2019,"lang":"en","type":"article","venue":"Acta Ophthalmologica","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute for Health and Care Research; Foundation Fighting Blindness; Howard Hughes Medical Institute","keywords":"Choroideremia; Retinal pigment epithelium; Retinal; Stargardt disease; Ophthalmology; Fundus (uterus); Autofluorescence; Medicine; Optical coherence tomography; Macular degeneration; Anatomy; Biology; Optics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003602932,0.0003249063,0.0002086291,0.001082227,0.0002827478,0.0003281022,0.000147882,0.00027125,0.00148537],"category_scores_gemma":[0.001890127,0.0001555504,0.0001863711,0.0004177058,0.0004159337,0.00028932,0.0002756132,0.0002388551,0.0001862277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002512179,"about_ca_system_score_gemma":0.0001586222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001612146,"about_ca_topic_score_gemma":0.001830643,"domain_scores_codex":[0.9997627,0.00004475587,0.00003745479,0.00006381301,0.00006000512,0.00003137359],"domain_scores_gemma":[0.9989391,0.0002738088,0.0004949572,0.00006114876,0.0001054245,0.0001256584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002119213,0.00001134322,0.987869,0.00001619967,0.00002727415,0.0008189947,0.00005323184,0.00005396904,0.009036675,0.00001532464,0.00003086113,0.001855249],"study_design_scores_gemma":[0.000003645249,0.00007833366,0.9959793,0.000005238497,0.00001733961,0.002921185,0.00006261221,0.0001510508,0.0006881267,0.00001307153,0.00007819371,0.000001932487],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994445,0.0001888503,0.0001034352,0.000007967539,0.000001053388,0.00000546595,0.0000309871,0.000003171212,0.0002145402],"genre_scores_gemma":[0.9997423,0.00005156917,0.0001024551,0.000003825129,0.000001886012,0.000002446993,0.00004467172,9.094329e-7,0.00004981196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001612146,"threshold_uncertainty_score":0.00496906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01234464967186118,"score_gpt":0.2339247940732857,"score_spread":0.2215801444014245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}