{"id":"W2985545877","doi":"10.1016/j.bmcl.2019.126783","title":"Formation of 5α-dihydrotestosterone from 5α-androstane-3α,17β-diol in prostate cancer LAPC-4 cells – Identifying inhibitors of non-classical pathways producing the most potent androgen","year":2019,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval","funders":"Faculté de Médecine, Université Laval; Mitacs","keywords":"Androstane; Dihydrotestosterone; Chemistry; Androgen; Testosterone (patch); Prostate cancer; Androgen receptor; IC50; Prostate; Endocrinology; Internal medicine; Stereochemistry; Pharmacology; Cancer; In vitro; Biochemistry; Hormone; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002545459,0.0004240462,0.0003941416,0.000374692,0.000199329,0.00035552,0.0003351149,0.0003059317,0.002209437],"category_scores_gemma":[0.0001212114,0.0002500384,0.0004453774,0.0003571366,0.0002302629,0.0002109854,0.0001611085,0.0006651772,0.0008762329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003388555,"about_ca_system_score_gemma":0.0004082201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001391621,"about_ca_topic_score_gemma":0.002445266,"domain_scores_codex":[0.9998096,0.00003376186,0.00001633654,0.00002587595,0.00006282183,0.00005164947],"domain_scores_gemma":[0.9999065,0.00002550385,0.00001223728,0.00001316493,0.00001568725,0.00002672831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002372304,0.00004486765,0.0001276516,0.00003639951,0.000009455528,0.00006412252,0.00001443879,0.00007928154,0.9982141,0.00008332805,0.0000936275,0.0009954427],"study_design_scores_gemma":[0.00002338042,0.0002096462,0.0008557782,0.000001269517,0.000008611475,0.00008058751,0.00001109633,0.0002243866,0.9973083,0.00001569688,0.001259045,0.00000218411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810259,0.00721659,0.004216602,0.0003427627,0.0001607256,0.00009098444,0.002170263,0.0002092805,0.00456701],"genre_scores_gemma":[0.9831288,0.002402219,0.002818116,0.0001091774,0.00003940937,0.00004999703,0.003804433,0.00003075167,0.007617053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002209437,"threshold_uncertainty_score":0.007391274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01680924037588159,"score_gpt":0.2541840220054449,"score_spread":0.2373747816295633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}