{"id":"W2985546444","doi":"10.1182/blood-2019-127826","title":"Inhibition of the MiR-185-PAK6-Mediated Survival and Metabolic Pathways Selectively Targets Drug-Resistant CML Stem/Progenitor Cells","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia; BC Cancer Agency; Terry Fox Research Institute","funders":"","keywords":"Cancer research; Stem cell; Biology; Myeloid leukemia; CD34; Progenitor cell; microRNA; Transcriptome; Tyrosine kinase; Gene expression profiling; Signal transduction; Gene expression; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001116761,0.000229536,0.0002224282,0.0001233021,0.0001123867,0.0002902516,0.0001296162,0.000147854,0.0009857612],"category_scores_gemma":[0.00008293169,0.0001275092,0.0002069974,0.0001083701,0.0001532722,0.0001482305,0.0001577013,0.0005334147,0.0004547301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001725716,"about_ca_system_score_gemma":0.0001754111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001758636,"about_ca_topic_score_gemma":0.0003278671,"domain_scores_codex":[0.9998883,0.000013932,0.00001149795,0.0000222079,0.00004181627,0.00002231354],"domain_scores_gemma":[0.9999692,0.000003972168,0.00001205173,0.000003414052,0.000003820565,0.000007563146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001738548,0.00004215244,0.0002518426,0.00008234524,0.000008171763,0.00003018578,0.00002096943,0.0001653123,0.9954051,0.0002037714,0.0001051157,0.003511152],"study_design_scores_gemma":[0.00002915992,0.0004120697,0.003573076,0.000005564869,0.00002509911,0.0002971124,0.0000228334,0.001491053,0.9873888,0.00006979061,0.006680719,0.000004639307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880462,0.002471498,0.00555646,0.000127244,0.00004915076,0.00009217201,0.000682275,0.0001968605,0.002778347],"genre_scores_gemma":[0.9934757,0.001046443,0.00321418,0.00006668142,0.000009366164,0.00005544478,0.0005878981,0.00001944414,0.001524796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009857612,"threshold_uncertainty_score":0.003297746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0100343710614842,"score_gpt":0.2080970961534062,"score_spread":0.198062725091922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}