{"id":"W2985606037","doi":"10.1038/s41467-019-12733-1","title":"A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Dental and Craniofacial Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Environmental Health Sciences; National Cancer Institute; U.S. Department of Health and Human Services; School of Medicine, New York University; National Institutes of Health; New York State Stem Cell Science; York University","keywords":"Melanoma; Melanocyte; Biology; Cancer research; Wnt signaling pathway; Malignant transformation; Stem cell; Microphthalmia-associated transcription factor; Cell biology; Gene; Signal transduction; Genetics; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001872491,0.0001707777,0.000132506,0.00006722821,0.0002421143,0.00005115846,0.0008492966,0.0002960108,0.00001426304],"category_scores_gemma":[0.00001229875,0.0001680988,0.000116241,0.00009312516,0.00006167493,0.0000126756,0.0003319171,0.0003557657,0.00002650678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000330479,"about_ca_system_score_gemma":0.000103819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008034377,"about_ca_topic_score_gemma":0.0001157495,"domain_scores_codex":[0.9989968,0.00009660723,0.0002035981,0.0003162087,0.0001806574,0.0002061223],"domain_scores_gemma":[0.9978492,0.00003842096,0.0001156697,0.001763887,0.0001067354,0.0001261268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003331078,0.0001218731,0.003219026,0.00001387481,0.00006408242,2.917317e-7,0.0000802241,0.0005662495,0.9924837,0.002033949,0.00123724,0.000146157],"study_design_scores_gemma":[0.001191676,0.00008582889,0.001296134,0.00002956367,0.00009407366,0.000005368727,0.0003638307,0.01372127,0.9686756,0.0001550062,0.01391189,0.0004697946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891597,0.005576003,0.001498271,0.0003617724,0.0001184669,0.0004264503,0.0001368541,0.00003810141,0.002684353],"genre_scores_gemma":[0.989366,0.000847516,0.005083835,0.0003279194,0.00005004532,0.0000487408,0.0006878746,0.00003358137,0.003554505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02380816,"threshold_uncertainty_score":0.685487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04614167401122821,"score_gpt":0.3138948569988095,"score_spread":0.2677531829875813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}