{"id":"W2985698126","doi":"10.1182/blood-2019-124291","title":"Pharmacodynamic Responses to CC-90009, a Novel Cereblon E3 Ligase Modulator, in a Phase I Dose-Escalation Study in Relapsed or Refractory Acute Myeloid Leukemia (R/R AML)","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Pharmacodynamics; Refractory (planetary science); Cereblon; Phases of clinical research; Pharmacology; Internal medicine; Ubiquitin ligase; Pharmacokinetics; Chemistry; Clinical trial; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000689886,0.0008053431,0.001058155,0.0003024297,0.0001808775,0.000556303,0.0004336757,0.0005342061,0.001391308],"category_scores_gemma":[0.0005230196,0.0002583653,0.0005293452,0.0003274407,0.0005370578,0.0004201723,0.0001871739,0.001946288,0.0003323266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008036164,"about_ca_system_score_gemma":0.000782656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006739069,"about_ca_topic_score_gemma":0.002512798,"domain_scores_codex":[0.9997374,0.00009272053,0.00001663904,0.00005174538,0.00004397248,0.00005741002],"domain_scores_gemma":[0.999619,0.00005038378,0.0001105093,0.00003081591,0.00002450685,0.0001647524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2575372,0.04371532,0.01746891,0.000751553,0.001279668,0.0003290749,0.0003845739,0.009173849,0.443272,0.0004159246,0.005965774,0.2197063],"study_design_scores_gemma":[0.1379541,0.6654786,0.09644839,0.00004201677,0.001297689,0.001284358,0.0001162979,0.006591109,0.08055753,0.0002930765,0.009820419,0.0001163908],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966339,0.001015471,0.0004278943,0.0001327879,0.0000232371,0.0004346982,0.0004811266,0.00009429452,0.0007566225],"genre_scores_gemma":[0.9955803,0.0006431887,0.001365355,0.000249713,0.0000457427,0.0004295431,0.0009487954,0.00002366776,0.0007137786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001391308,"threshold_uncertainty_score":0.005830705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01381981202338931,"score_gpt":0.2996691122913532,"score_spread":0.285849300267964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}