{"id":"W2985708461","doi":"10.3390/ijms20225655","title":"Claudin-2: Roles beyond Permeability Functions","year":2019,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Toronto; Kidney Foundation of Canada","keywords":"Claudin; Cell biology; Biology; Signal transduction; Tight junction; Paracellular transport; Intracellular; Homeostasis; Cell signaling; Inflammation; Permeability (electromagnetism); Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006397222,0.0002949232,0.0008471897,0.0005853893,0.0001965974,0.0002676192,0.001625372,0.000136422,0.0001830813],"category_scores_gemma":[0.0008387021,0.0001983763,0.0008293942,0.0005116239,0.000566229,0.000369781,0.0002448715,0.0005090856,0.0001144721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000123178,"about_ca_system_score_gemma":0.0006427957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000218368,"about_ca_topic_score_gemma":0.000001696028,"domain_scores_codex":[0.996656,0.0002743028,0.0008578077,0.0004676464,0.001514443,0.000229785],"domain_scores_gemma":[0.9977807,0.0004128822,0.001099572,0.0002134333,0.0003959425,0.00009745007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001437046,0.00006117907,0.00002403592,0.0002654278,0.000215257,0.0001406601,0.0001079954,0.0000617857,0.0004418962,0.003454947,0.001319965,0.9938925],"study_design_scores_gemma":[0.0001357154,0.0001401118,0.000007399954,0.0007309515,0.0002397391,0.001031609,0.0000765101,0.000006177277,0.0002596012,0.001162271,0.9960012,0.0002087175],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002266116,0.9815081,0.0009722919,0.0003432786,0.007579468,0.0001707736,0.00005969232,0.00001662036,0.009123142],"genre_scores_gemma":[0.003480786,0.9948226,0.0002156477,0.0004966176,0.0004999213,0.000006398686,0.000002191429,0.00001724071,0.0004586227],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9946812,"threshold_uncertainty_score":0.8089551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07357621515445509,"score_gpt":0.3661681059895617,"score_spread":0.2925918908351066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}