{"id":"W2985734235","doi":"10.1101/833475","title":"Antiretroviral APOBEC3 Cytidine Deaminases Alter HIV-1 Provirus Integration Site Profiles","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Ottawa; Western University","funders":"Canadian Institutes of Health Research","keywords":"Cytidine deaminase; Biology; Provirus; Somatic hypermutation; Integrase; Genetics; DNA; Integrases; Gene; Transcription (linguistics); Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001094093,0.000207215,0.0001631771,0.0002012057,0.0001010353,0.0003187745,0.0001971429,0.0003035751,0.007492213],"category_scores_gemma":[0.0001274348,0.0001246795,0.0001953949,0.0001835186,0.00009955026,0.0001610541,0.0001040141,0.000565085,0.0006673275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002845768,"about_ca_system_score_gemma":0.0001238743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001195681,"about_ca_topic_score_gemma":0.001210841,"domain_scores_codex":[0.9999164,0.00000795753,0.00000351278,0.00002102461,0.00002780223,0.00002331819],"domain_scores_gemma":[0.9999436,0.00001520378,0.00001414901,0.00000594412,0.000007244947,0.00001376945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003882369,0.0000576882,0.0007476381,0.0001280446,0.00002253738,0.00005444446,0.00001298966,0.0007121713,0.9891213,0.0005014336,0.0009553436,0.007298154],"study_design_scores_gemma":[0.00005558952,0.0003324105,0.006705124,0.00001788345,0.00004657506,0.0001530314,0.00003779216,0.00561944,0.9805312,0.000396973,0.006089882,0.0000140653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733297,0.003351652,0.006220748,0.0005797338,0.000153125,0.00005045177,0.006606665,0.0006069932,0.009100818],"genre_scores_gemma":[0.9897798,0.0009115021,0.003323542,0.000156621,0.000009070968,0.00001933942,0.00165786,0.00003067978,0.004111495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007492213,"threshold_uncertainty_score":0.02506393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01362680141547712,"score_gpt":0.2346198781554001,"score_spread":0.220993076739923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}