{"id":"W2985886576","doi":"10.7554/elife.11612.024","title":"Author response: Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation","year":2015,"lang":"en","type":"peer-review","venue":"","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"","keywords":"mTORC1; PI3K/AKT/mTOR pathway; Macrophage polarization; Macrophage; Protein kinase B; Cell biology; Biology; Chemokine; Signal transduction; Immune system; Computational biology; Cancer research; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004615518,0.001404043,0.001039358,0.0007493921,0.001282062,0.002734157,0.00112879,0.003064913,0.1506048],"category_scores_gemma":[0.001098655,0.0006152396,0.001163858,0.0005415899,0.0009586269,0.001198725,0.002114267,0.003279958,0.06242832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001064175,"about_ca_system_score_gemma":0.001207186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008540718,"about_ca_topic_score_gemma":0.001565193,"domain_scores_codex":[0.9992027,0.00006396139,0.00004101462,0.0002392007,0.0002273666,0.0002258452],"domain_scores_gemma":[0.9994175,0.00004424403,0.00007735001,0.00003943583,0.0002035767,0.0002178821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005111099,0.0005648489,0.003544894,0.003507441,0.0002749241,0.001575042,0.0004018086,0.002616317,0.1705632,0.01469969,0.6744359,0.122705],"study_design_scores_gemma":[0.0008154937,0.0006249322,0.01084711,0.0005179766,0.0001189914,0.00113766,0.001136532,0.003243228,0.1016666,0.004281468,0.8754618,0.0001481821],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.1309057,0.07759941,0.02050109,0.1069078,0.1489244,0.001516353,0.02593798,0.0114365,0.4762709],"genre_scores_gemma":[0.3646623,0.02451764,0.007187298,0.03382096,0.008567962,0.000762622,0.01552801,0.00174721,0.5432061],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.1506048,"threshold_uncertainty_score":0.5038233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03305012569302943,"score_gpt":0.3251663394553363,"score_spread":0.2921162137623068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}