{"id":"W2985894798","doi":"10.3390/genes10110879","title":"The RB1 Story: Characterization and Cloning of the First Tumor Suppressor Gene","year":2019,"lang":"en","type":"review","venue":"Genes","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Hyundai Hope On Wheels; Ögonfonden; National Cancer Institute; Children's Hospital Los Angeles; Research to Prevent Blindness; Knights Templar Eye Foundation","keywords":"Retinoblastoma; Genetics; Biology; Suppressor; Tumor suppressor gene; Gene; Carcinogenesis; Cloning (programming); Malignancy; Computational biology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001220503,0.0001416485,0.0005523088,0.00002393635,0.0001702524,0.000008872115,0.00009633268,0.0001096123,0.000009408504],"category_scores_gemma":[0.00003373033,0.00006421941,0.0001469827,0.00006298003,0.00007992365,0.00001600729,0.00006911674,0.0001236427,0.00001702236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002953015,"about_ca_system_score_gemma":0.0001242519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002781454,"about_ca_topic_score_gemma":0.000004532545,"domain_scores_codex":[0.9993919,0.00009435861,0.0001672562,0.0001513456,0.00008952018,0.0001056469],"domain_scores_gemma":[0.9992785,0.00009345942,0.0002402013,0.000337507,0.00002930139,0.00002102407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000255363,0.00006371045,0.005573359,0.008446066,0.0007565386,0.00001879464,0.00008785532,1.159354e-7,0.0001749004,0.00005018515,0.0001529397,0.98465],"study_design_scores_gemma":[0.0002400553,0.00005832126,0.004202807,0.001401046,0.001406219,0.00007615185,0.00000363893,0.000002089843,0.0001526646,0.000001516159,0.992401,0.00005451512],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009560253,0.9890146,0.000001972638,0.0001797937,0.0004139511,0.0007392113,0.00003737388,0.000007263121,0.00004559882],"genre_scores_gemma":[0.0004800103,0.9978726,0.00001608602,0.00004482268,0.0001326425,0.00005065512,0.0001152953,0.0000208194,0.001267097],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9922481,"threshold_uncertainty_score":0.2618791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03689867153187798,"score_gpt":0.3095905139227106,"score_spread":0.2726918423908327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}