{"id":"W2985913611","doi":"10.1093/neuonc/noz175.1151","title":"SCIDOT-15. DISRUPTING THE BLOOD-BRAIN BARRIER IN NEURO-ONCOLOGY: INNOVATIONS, ACHIEVEMENTS, AND LESSONS LEARNED FROM CLINICAL TRIALS","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Lanthanide and Transition Metal Complexes","field":"Materials Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"","keywords":"Medicine; Tolerability; Blood–brain barrier; Clinical trial; Oncology; Internal medicine; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.009002908,0.000277797,0.001084417,0.0001756235,0.0002766825,0.0001346323,0.0005253531,0.0003164325,0.001218326],"category_scores_gemma":[0.005372991,0.000198244,0.0001484426,0.0004315787,0.0004154857,0.0002939813,0.0003326224,0.0008108725,0.0003221068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004835303,"about_ca_system_score_gemma":0.0003709313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001905196,"about_ca_topic_score_gemma":0.0003866552,"domain_scores_codex":[0.9905372,0.006134426,0.001602022,0.0008929463,0.0003104974,0.0005229322],"domain_scores_gemma":[0.9842476,0.01433702,0.0006170686,0.0005582896,0.00009396998,0.0001460764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003191494,0.0002572485,0.01676888,0.00001077819,0.00003272904,0.00008984076,0.000415487,0.00001649967,0.9647791,0.003430154,0.0008619235,0.01301818],"study_design_scores_gemma":[0.02398836,0.005207401,0.07834474,0.0001003331,0.0006506131,0.0002354063,0.002190215,0.0009819195,0.1653363,0.02412036,0.6975304,0.001313915],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9571455,0.0001180478,0.0001090088,0.03867476,0.001937479,0.0008050859,0.0001511196,0.00008007326,0.000978987],"genre_scores_gemma":[0.9809658,0.0001973902,0.0009323328,0.01723555,0.0004391039,0.00007618993,0.00004810674,0.00003567156,0.00006988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7994428,"threshold_uncertainty_score":0.9996947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1602026846540784,"score_gpt":0.4224061087711337,"score_spread":0.2622034241170552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}