{"id":"W2985913611","doi":"10.1093/neuonc/noz175.1151","title":"SCIDOT-15. DISRUPTING THE BLOOD-BRAIN BARRIER IN NEURO-ONCOLOGY: INNOVATIONS, ACHIEVEMENTS, AND LESSONS LEARNED FROM CLINICAL TRIALS","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Lanthanide and Transition Metal Complexes","field":"Materials Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"","keywords":"Medicine; Tolerability; Blood–brain barrier; Clinical trial; Oncology; Internal medicine; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01859345,0.0008349029,0.002936896,0.002624616,0.0004265088,0.003600742,0.001305392,0.002229068,0.01071111],"category_scores_gemma":[0.01720707,0.0002807204,0.003529856,0.002911923,0.001039958,0.002525938,0.00137919,0.002238016,0.002442321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00119704,"about_ca_system_score_gemma":0.004714141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004490151,"about_ca_topic_score_gemma":0.001154117,"domain_scores_codex":[0.9916531,0.004645597,0.001934097,0.0003906355,0.001117444,0.0002590111],"domain_scores_gemma":[0.9836572,0.009034511,0.003121121,0.0006535503,0.002568579,0.0009650348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.01613648,0.0007596273,0.001549192,0.2421792,0.003640455,0.0002688039,0.0002605717,0.00059255,0.004522299,0.005915156,0.03125912,0.6929165],"study_design_scores_gemma":[0.02580038,0.02580657,0.01053234,0.2623249,0.01603396,0.001206632,0.0005388773,0.001174767,0.007486905,0.01290752,0.6359487,0.0002384244],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01009463,0.9546724,0.001830105,0.01065392,0.001765412,0.002622365,0.004276737,0.0002471553,0.01383729],"genre_scores_gemma":[0.07060068,0.8893751,0.01132463,0.01260037,0.00199629,0.004274991,0.005788769,0.0001305471,0.003908627],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01859345,"threshold_uncertainty_score":0.0983327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1602026846540784,"score_gpt":0.4224061087711337,"score_spread":0.2622034241170552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}