{"id":"W2985916567","doi":"10.1093/jac/dkz468","title":"In vitro selection of aztreonam/avibactam resistance in dual-carbapenemase-producing Klebsiella pneumoniae","year":2019,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; National Institutes of Health; National Institute of Allergy and Infectious Diseases; U.S. Department of Veterans Affairs","keywords":"Aztreonam; Klebsiella pneumoniae; Microbiology; Avibactam; Ceftazidime/avibactam; Broth microdilution; Plasmid; Biology; Minimum inhibitory concentration; Antibiotic resistance; Antibiotics; Escherichia coli; Gene; Genetics; Imipenem","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000387144,0.0004767819,0.0006535922,0.0002036641,0.0001589455,0.0004421768,0.0004562002,0.0003660453,0.0005658654],"category_scores_gemma":[0.0004814813,0.0002686831,0.0003543739,0.0002146193,0.0001413689,0.0001556795,0.0004797811,0.0004870974,0.0003820553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003159079,"about_ca_system_score_gemma":0.0002210744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001729664,"about_ca_topic_score_gemma":0.002347402,"domain_scores_codex":[0.9991629,0.0002053275,0.0001583178,0.0001437866,0.000229031,0.0001005978],"domain_scores_gemma":[0.9993788,0.0002021549,0.0001356891,0.000105108,0.0001035941,0.00007452221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008819533,0.0000492931,0.001003191,0.00004459508,0.00001448363,0.00004295405,0.00002596603,0.0001071758,0.9977844,0.000013682,0.00002249565,0.0008036954],"study_design_scores_gemma":[0.0000113178,0.0006705474,0.005204921,0.000007866135,0.00003334181,0.000365667,0.00002734205,0.001225274,0.9918767,0.000009736659,0.0005582193,0.000009014329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942958,0.0009842217,0.003429142,0.00004970551,0.00002746646,0.00005069476,0.0004989679,0.00004725051,0.0006168205],"genre_scores_gemma":[0.9847518,0.0006707972,0.01146543,0.00006047054,0.00001885839,0.00006841879,0.001492523,0.00003349921,0.001438278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001729664,"threshold_uncertainty_score":0.003439188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004459960528032974,"score_gpt":0.2309540387217576,"score_spread":0.2264940781937246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}