{"id":"W2985958489","doi":"10.1358/dot.2019.55.10.3045038","title":"Viltolarsen for the treatment of Duchenne muscular dystrophy","year":2019,"lang":"en","type":"review","venue":"Drugs of today","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Muscular Dystrophy Canada; University of Alberta","funders":"","keywords":"Duchenne muscular dystrophy; Dystrophin; Exon skipping; Exon; Medicine; Morpholino; RNA splicing; Muscular dystrophy; Alternative splicing; Bioinformatics; Genetics; Internal medicine; Gene; Gene knockdown; RNA; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001907824,0.0005162155,0.0008082153,0.001478208,0.0001754982,0.0004379663,0.0005319123,0.0005862472,0.004290409],"category_scores_gemma":[0.0002131579,0.0001366819,0.0003594915,0.0008533392,0.0001844913,0.0004977913,0.0003245741,0.001332556,0.001893388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002771605,"about_ca_system_score_gemma":0.0003464942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004258982,"about_ca_topic_score_gemma":0.001132265,"domain_scores_codex":[0.9999181,0.00001270574,0.0000133248,0.00001716711,0.00002917485,0.000009457696],"domain_scores_gemma":[0.9999335,0.00003009591,0.0000124285,0.00000188703,0.00001252453,0.000009616278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0001561001,0.00009947773,0.000119222,0.01116017,0.0001008042,0.0002889163,0.0000416981,0.0002043903,0.003871831,0.001392191,0.01718303,0.9653823],"study_design_scores_gemma":[0.00006974518,0.0002752652,0.001079367,0.001979032,0.0001594271,0.003021166,0.00003585534,0.00008614228,0.001640971,0.0007483301,0.9908878,0.00001683766],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005125579,0.9970067,0.000172956,0.0001838198,0.0001595482,0.000008088312,0.00003878837,0.00001849947,0.001899028],"genre_scores_gemma":[0.003192407,0.9943525,0.0002968449,0.0002824375,0.0001237883,0.00001233712,0.0001015267,0.000003982548,0.001634303],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004290409,"threshold_uncertainty_score":0.0143528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03020348874980639,"score_gpt":0.3216006072539669,"score_spread":0.2913971185041606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}