{"id":"W2986016481","doi":"10.1007/s00253-019-10135-3","title":"Construction and application of an HSP70 promoter-inducible genome editing system in transgenic silkworm to induce resistance to Nosema bombycis","year":2019,"lang":"en","type":"article","venue":"Applied Microbiology and Biotechnology","topic":"Parasitic Infections and Diagnostics","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ministry of Agriculture","funders":"Chongqing Postdoctoral Science Special Foundation; Natural Science Foundation of Chongqing; China Postdoctoral Science Foundation; National Natural Science Foundation of China","keywords":"Microsporidia; Biology; Genome editing; Transgene; Genome; Nosema; Cas9; CRISPR; Gene; Microsporidiosis; Genetics; Intracellular parasite; RNA interference; Microbiology; Spore; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001538882,0.000330205,0.0002103888,0.0002846262,0.0001725444,0.0002200618,0.0002951349,0.0002920163,0.0007887892],"category_scores_gemma":[0.00009521132,0.0002121358,0.0003327952,0.0002009166,0.0001829932,0.0001506843,0.0002662244,0.0006815442,0.0002931279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002356264,"about_ca_system_score_gemma":0.0002080054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007552084,"about_ca_topic_score_gemma":0.001169685,"domain_scores_codex":[0.9998732,0.00001510282,0.00001651198,0.00003245932,0.00004029578,0.00002245229],"domain_scores_gemma":[0.9999038,0.000018156,0.00003180851,0.00001316075,0.000009192268,0.00002387009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001383618,0.000006895835,0.00004263444,0.00001450749,0.000001916834,0.00002384684,0.00001012688,0.00002894072,0.9992785,0.00006851029,0.0000099044,0.0005004787],"study_design_scores_gemma":[0.00001407396,0.00008195976,0.002788264,0.000005642139,0.00002835208,0.000158148,0.00002844671,0.001195811,0.9921741,0.00004226006,0.003476067,0.000006787919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9563844,0.0006417655,0.03812838,0.0001964785,0.00009119113,0.0002173568,0.001062903,0.0003837064,0.002893901],"genre_scores_gemma":[0.9745798,0.0006504746,0.01548037,0.00007479334,0.0000129492,0.0001113378,0.001807928,0.00009939,0.007182958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007887892,"threshold_uncertainty_score":0.002638698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004239126751215128,"score_gpt":0.207698931582536,"score_spread":0.2034598048313208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}