{"id":"W2986016481","doi":"10.1007/s00253-019-10135-3","title":"Construction and application of an HSP70 promoter-inducible genome editing system in transgenic silkworm to induce resistance to Nosema bombycis","year":2019,"lang":"en","type":"article","venue":"Applied Microbiology and Biotechnology","topic":"Parasitic Infections and Diagnostics","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ministry of Agriculture","funders":"Chongqing Postdoctoral Science Special Foundation; Natural Science Foundation of Chongqing; China Postdoctoral Science Foundation; National Natural Science Foundation of China","keywords":"Microsporidia; Biology; Genome editing; Transgene; Genome; Nosema; Cas9; CRISPR; Gene; Microsporidiosis; Genetics; Intracellular parasite; RNA interference; Microbiology; Spore; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030533,0.0002091181,0.000458423,0.0004545083,0.000115845,0.000006725418,0.0001627813,0.0009826167,0.00001414163],"category_scores_gemma":[0.0000268089,0.0002077227,0.00002355192,0.0003991208,0.0003248646,0.00004186609,0.0000968917,0.0003410308,0.0001046585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006254164,"about_ca_system_score_gemma":0.00003310181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006905015,"about_ca_topic_score_gemma":0.0003091839,"domain_scores_codex":[0.9984829,0.00006213783,0.000419361,0.0006320029,0.00001316912,0.0003904512],"domain_scores_gemma":[0.9993333,0.00009251868,0.000133335,0.0003599508,0.00004486052,0.00003606162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001332681,0.00006824479,0.001686176,0.00007556382,0.00003477325,0.000001209138,0.0002724715,0.000007589766,0.9683325,0.02265763,0.0000113217,0.006719215],"study_design_scores_gemma":[0.001260907,0.0004749853,0.005644171,0.00006206366,0.00003451261,0.0003316634,0.001166003,0.000003069084,0.9830459,0.0002919142,0.007390782,0.0002940753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949181,0.0002721543,0.002481339,0.0003685091,0.0002581443,0.001103263,0.00008501879,0.00009779759,0.0004156546],"genre_scores_gemma":[0.997072,0.00002505751,0.002505196,0.0001255923,0.00002111867,0.0001099369,0.00009329447,0.00001419233,0.00003365097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02236572,"threshold_uncertainty_score":0.8470686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004239126751215128,"score_gpt":0.207698931582536,"score_spread":0.2034598048313208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}