{"id":"W2986030647","doi":"10.1182/blood-2019-127005","title":"Prophylactic Antibiotic Use and Risk of Meningococcal Infections in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Treated with Eculizumab Who Received Meningococcal Vaccination: Results from the International PNH Registry","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Eculizumab; Medicine; Paroxysmal nocturnal hemoglobinuria; Vaccination; Internal medicine; Pediatrics; Neisseria meningitidis; Meningococcal vaccine; Immunology; Immunization; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000637849,0.0001744956,0.0003068021,0.0009476579,0.000136041,0.0004472813,0.0003428104,0.0002935046,0.0007692838],"category_scores_gemma":[0.001916661,0.0001725953,0.0005340083,0.001121354,0.0001292071,0.0004569904,0.0004054393,0.0004164584,0.0001611146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001932113,"about_ca_system_score_gemma":0.0002100953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002711823,"about_ca_topic_score_gemma":0.00253282,"domain_scores_codex":[0.9994635,0.0001400298,0.0001195701,0.0001034912,0.000114592,0.00005870366],"domain_scores_gemma":[0.9983665,0.0002151948,0.001088212,0.00008704534,0.00009906678,0.0001439392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001166774,0.00002398673,0.9982602,0.00002368849,0.00006869124,0.00002428552,0.00002160203,0.00004052729,0.00004624661,0.00001154988,0.0001762643,0.001186266],"study_design_scores_gemma":[0.00001183001,0.00006732182,0.9991922,0.00001877931,0.00005557418,0.0001866131,0.00005215515,0.0001606948,0.00004153447,0.00001043603,0.000199901,0.000002915416],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945478,0.001196926,0.0000961035,0.00007579408,0.000009071765,0.00001524173,0.003228921,0.000008862285,0.0008212263],"genre_scores_gemma":[0.9967883,0.0006308497,0.0001226922,0.00003983095,0.00001502126,0.00002052689,0.002276148,0.000002713639,0.000103985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002711823,"threshold_uncertainty_score":0.005392075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006851578380216747,"score_gpt":0.1993162677628336,"score_spread":0.1924646893826168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}