{"id":"W2986040087","doi":"10.1182/blood-2019-128211","title":"Preliminary Report of MANIFEST, a Phase 2 Study of CPI-0610, a Bromodomain and Extraterminal Domain Inhibitor (BETi), in Combination with Ruxolitinib, in JAK Inhibitor (JAKi) Treatment Naïve Myelofibrosis Patients","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; McMaster University","funders":"","keywords":"Ruxolitinib; Medicine; Myelofibrosis; Tofacitinib; Myeloproliferative neoplasm; Janus kinase; Internal medicine; Venetoclax; Cancer research; Bone marrow; Leukemia; Cytokine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002377431,0.00117556,0.001290716,0.0002932358,0.0005141892,0.001282133,0.0007945751,0.001636364,0.005705785],"category_scores_gemma":[0.001391844,0.0004589702,0.001453612,0.0002831452,0.0006026145,0.001037315,0.0003397715,0.004162617,0.002222383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006949721,"about_ca_system_score_gemma":0.001500298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009145318,"about_ca_topic_score_gemma":0.002797337,"domain_scores_codex":[0.9995114,0.0001970933,0.00004449021,0.00007843712,0.00007267584,0.00009600331],"domain_scores_gemma":[0.9989451,0.0001848233,0.0001375897,0.00007796613,0.0001205716,0.0005341592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2586511,0.08836434,0.01694505,0.003292207,0.004577785,0.003775315,0.001281835,0.005005143,0.2243735,0.001542057,0.06748109,0.3247107],"study_design_scores_gemma":[0.2010652,0.669252,0.03201587,0.0002064841,0.002435906,0.003749517,0.0002640989,0.002627089,0.03220691,0.001112331,0.0549556,0.0001089604],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9286452,0.0162711,0.006476314,0.007503747,0.001184679,0.006048421,0.01444778,0.0008545298,0.01856826],"genre_scores_gemma":[0.9530496,0.006899198,0.004461606,0.00598139,0.0005776241,0.003150715,0.01333332,0.0001457853,0.01240092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005705785,"threshold_uncertainty_score":0.01908773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01054408220360751,"score_gpt":0.2641798675588689,"score_spread":0.2536357853552614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}