{"id":"W2986049132","doi":"10.1111/jphp.13198","title":"Evaluation of the time-dependent antiproliferative activity and liver microsome stability of 3 phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as promising CYP1A1-dependent antimicrotubule prodrugs","year":2019,"lang":"en","type":"article","venue":"Journal of Pharmacy and Pharmacology","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval; Centre hospitalier de l'Université Laval; Hôpital Saint-François d'Assise","funders":"Fonds de Recherche du Québec - Santé","keywords":"Microsome; Sulforhodamine B; Microsoma; Human liver; In vitro; Prodrug; Pharmacology; Chemistry; Biochemistry; Biology; Cytotoxicity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003059378,0.0002541268,0.0006536403,0.00006413885,0.0001133686,0.00002456662,0.0002784164,0.0001270712,0.002680624],"category_scores_gemma":[0.000197994,0.0001621409,0.0001729931,0.00009942178,0.0002727959,0.0003138165,0.0002282345,0.0004967715,0.000003733667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001048778,"about_ca_system_score_gemma":0.0003008922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005489524,"about_ca_topic_score_gemma":0.000002862985,"domain_scores_codex":[0.9973668,0.0007773401,0.0006384063,0.0003374381,0.0006177817,0.0002622013],"domain_scores_gemma":[0.9972448,0.0005826775,0.001187131,0.0001540289,0.0007223313,0.0001090025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001612732,0.0008281288,0.03591675,0.0003217258,0.0003288995,0.00000460296,0.0004896728,0.00003450552,0.9486737,0.000003268826,0.00002538217,0.01176059],"study_design_scores_gemma":[0.003837036,0.000149583,0.007595041,0.0000715286,0.0006293097,0.000154631,0.0001068082,0.002264085,0.9847479,0.000165763,0.000106898,0.00017143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968721,0.001390881,0.000002745416,0.0003851352,0.0002507961,0.0005033804,0.00006835041,0.0000074712,0.0005191682],"genre_scores_gemma":[0.9990488,0.0006099773,0.00003456184,0.00008268098,0.0001594406,0.000007844606,0.000001042864,0.00001361304,0.00004209065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03607414,"threshold_uncertainty_score":0.9982311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03194847467122761,"score_gpt":0.307693310740967,"score_spread":0.2757448360697393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}