{"id":"W2986049132","doi":"10.1111/jphp.13198","title":"Evaluation of the time-dependent antiproliferative activity and liver microsome stability of 3 phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as promising CYP1A1-dependent antimicrotubule prodrugs","year":2019,"lang":"en","type":"article","venue":"Journal of Pharmacy and Pharmacology","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval; Centre hospitalier de l'Université Laval; Hôpital Saint-François d'Assise","funders":"Fonds de Recherche du Québec - Santé","keywords":"Microsome; Sulforhodamine B; Microsoma; Human liver; In vitro; Prodrug; Pharmacology; Chemistry; Biochemistry; Biology; Cytotoxicity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002004027,0.0003370497,0.0002430291,0.0001821586,0.00009373106,0.0001288189,0.00009648679,0.0001718764,0.00113085],"category_scores_gemma":[0.0002117321,0.00009343888,0.0002168771,0.0001862888,0.00009496677,0.0001332122,0.00006901553,0.0002308247,0.0003100286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001808851,"about_ca_system_score_gemma":0.0001736595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005436626,"about_ca_topic_score_gemma":0.0008556846,"domain_scores_codex":[0.9999059,0.00003151833,0.000008058414,0.00001517687,0.00002287861,0.00001636813],"domain_scores_gemma":[0.999855,0.00003609439,0.00004961711,0.00001212448,0.00003448598,0.0000126788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002635418,0.00003261852,0.0004349914,0.0000467747,0.00000945262,0.00003516746,0.00001152087,0.0001303369,0.9966801,0.00001503201,0.00002151879,0.002318953],"study_design_scores_gemma":[0.000009269052,0.001547157,0.004279105,0.000002575062,0.00002202306,0.0001118542,0.00001303113,0.0003117404,0.9930317,0.000005349516,0.0006632017,0.000002935277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934475,0.003472416,0.002001113,0.00004649028,0.00001040559,0.00003248545,0.0002831885,0.00004648677,0.0006599515],"genre_scores_gemma":[0.9942328,0.001852545,0.001805756,0.00002084844,0.000009577919,0.00003519135,0.0005333778,0.00001258845,0.001497252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00113085,"threshold_uncertainty_score":0.003783047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03194847467122761,"score_gpt":0.307693310740967,"score_spread":0.2757448360697393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}