{"id":"W2986081689","doi":"10.1016/j.bbalip.2019.158555","title":"Surf4 regulates expression of proprotein convertase subtilisin/kexin type 9 (PCSK9) but is not required for PCSK9 secretion in cultured human hepatocytes","year":2019,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"PCSK9; Endocrinology; Internal medicine; LDL receptor; Kexin; Very low-density lipoprotein; Apolipoprotein B; Apolipoprotein E; Lipoprotein; Cholesterol; Triglyceride; Biology; Chemistry; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002461319,0.0004153791,0.0004178474,0.0005551042,0.0003467078,0.0007270008,0.0003109029,0.0004803629,0.004646179],"category_scores_gemma":[0.0003594465,0.0004573312,0.0007504538,0.0002574162,0.0005337246,0.0003888208,0.0004933919,0.0006667264,0.001484768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007114541,"about_ca_system_score_gemma":0.0004822775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00176617,"about_ca_topic_score_gemma":0.001484414,"domain_scores_codex":[0.9995388,0.00009898759,0.00005291223,0.00009312674,0.00008956098,0.0001265851],"domain_scores_gemma":[0.9996786,0.00006095359,0.00007695453,0.00005686052,0.00004630785,0.00008028292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006217467,0.00002216355,0.0005405018,0.00003085894,0.0000127378,0.0001838881,0.00001868435,0.00005331448,0.9976821,0.0001192071,0.0001314363,0.000583277],"study_design_scores_gemma":[0.00008217293,0.0002834194,0.02360263,0.00001000255,0.00004926373,0.000773981,0.0002076402,0.001344396,0.9695293,0.0001566547,0.003942862,0.00001772375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936793,0.001240461,0.001176026,0.0002129863,0.0001134172,0.00001734589,0.001050621,0.0001070091,0.002402862],"genre_scores_gemma":[0.9901327,0.000340718,0.0008069701,0.0001183328,0.0000251838,0.00002726,0.002085959,0.00007312932,0.006389811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004646179,"threshold_uncertainty_score":0.01554304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01415620092011085,"score_gpt":0.2661669797312339,"score_spread":0.252010778811123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}