{"id":"W2986107793","doi":"10.1101/831008","title":"HIV Envelope Trimer-Elicited Autologous Neutralizing Antibodies Bind a Region Overlapping the N332 Glycan Supersite","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institutes of Health; amfAR, The Foundation for AIDS Research; Bill and Melinda Gates Foundation","keywords":"Glycan; Epitope; Antibody; Neutralization; Monoclonal antibody; Glycoprotein; Trimer; Virology; Chemistry; Biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001317853,0.0002964991,0.0001242942,0.0001274865,0.0001453435,0.0002269034,0.0001946603,0.0003227425,0.00161491],"category_scores_gemma":[0.0001317361,0.0001213544,0.0002110426,0.0000913884,0.000118469,0.00009795564,0.000200758,0.0005599983,0.0004934613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003714993,"about_ca_system_score_gemma":0.0001458263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001673792,"about_ca_topic_score_gemma":0.002008365,"domain_scores_codex":[0.9999099,0.00001192046,0.000004138483,0.00001970389,0.00002473089,0.00002967712],"domain_scores_gemma":[0.9999493,0.00001276542,0.000008415112,0.000009274173,0.00000868348,0.00001144352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005760621,0.00001604202,0.0004728227,0.00001111069,0.000006406412,0.00003337679,0.00001200693,0.00006230071,0.9985703,0.00008928318,0.00006314164,0.000605597],"study_design_scores_gemma":[0.00001789561,0.0001859154,0.01227271,0.000006818485,0.00001423387,0.000324555,0.00003852123,0.001679517,0.9828331,0.00007063562,0.002552787,0.000003459077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947,0.0002460493,0.00201981,0.00006003148,0.00001218619,0.00001789737,0.0001804088,0.0000233915,0.00274037],"genre_scores_gemma":[0.9936544,0.0001549286,0.002267225,0.0001444568,0.000006848998,0.00001068162,0.0008300297,0.00001801805,0.00291338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001673792,"threshold_uncertainty_score":0.005402386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02179813867463582,"score_gpt":0.2361974354346835,"score_spread":0.2143992967600477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}