{"id":"W2986115900","doi":"10.3389/fmicb.2019.02608","title":"Emerging Variants of the Integrative and Conjugant Element ICEMh1 in Livestock Pathogens: Structural Insights, Potential Host Range, and Implications for Bacterial Fitness and Antimicrobial Therapy","year":2019,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Microbial infections and disease research","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Beef Cattle Research Council; Agriculture and Agri-Food Canada; Natural Sciences and Engineering Research Council of Canada; Alberta Livestock and Meat Agency; Alberta Agriculture and Forestry","keywords":"Biology; Pasteurella multocida; Antimicrobial; Genome; Antibiotic resistance; Gene; Bovine respiratory disease; Genetics; Microbiology; Host adaptation; Horizontal gene transfer; Computational biology; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001304278,0.0001652888,0.0001485328,0.0002272836,0.00009367208,0.0002370499,0.0001612766,0.0002617789,0.0004523406],"category_scores_gemma":[0.0001769379,0.0000820642,0.0001549018,0.000190573,0.0002015653,0.000220385,0.0002065142,0.0003195732,0.0001473765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001774068,"about_ca_system_score_gemma":0.00009865194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000217914,"about_ca_topic_score_gemma":0.0002450534,"domain_scores_codex":[0.9999168,0.000012685,0.000005072018,0.00001835721,0.00002465313,0.0000223828],"domain_scores_gemma":[0.9998652,0.0000286506,0.00005172925,0.00001789905,0.00001224314,0.00002422476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006489672,0.00001346161,0.004386276,0.00002826235,0.000003273892,0.0001201196,0.00006378094,0.00005732262,0.9929838,0.00009641534,0.000007489149,0.002174876],"study_design_scores_gemma":[0.00001477448,0.0009725828,0.2196628,0.00002518186,0.00005417336,0.004303406,0.0007592581,0.002485445,0.7668182,0.0003788056,0.004508336,0.00001707328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985399,0.0003150886,0.0008335417,0.00002070101,0.000001706768,0.000003857845,0.00003936435,0.000007143428,0.0002387802],"genre_scores_gemma":[0.9978486,0.0001642612,0.001575849,0.0000111041,0.000003747851,0.000003077106,0.0001537509,0.000003787772,0.000235734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004523406,"threshold_uncertainty_score":0.001513243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007485099713668363,"score_gpt":0.2480236312123358,"score_spread":0.2405385314986675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}