{"id":"W2986162201","doi":"10.1158/2159-8290.cd-19-0644","title":"Single-Cell RNA Sequencing Reveals Stromal Evolution into LRRC15+ Myofibroblasts as a Determinant of Patient Response to Cancer Immunotherapy","year":2019,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":846,"is_retracted":false,"has_abstract":true,"ca_institutions":"Microsemi (Canada)","funders":"Genentech","keywords":"Immunotherapy; Stromal cell; Cancer research; Tumor microenvironment; Pancreatic cancer; Cancer-Associated Fibroblasts; Cancer; Cancer immunotherapy; Adenocarcinoma; Biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003632865,0.0002116232,0.0006500377,0.0002077257,0.00005353598,0.00002114979,0.0001457194,0.0001350525,0.0003051482],"category_scores_gemma":[0.0001165873,0.0001752487,0.0001351003,0.0002907021,0.0001153129,0.0002206941,0.00008749521,0.0001969809,0.00004832264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002383009,"about_ca_system_score_gemma":0.002118209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003429288,"about_ca_topic_score_gemma":0.000140762,"domain_scores_codex":[0.9979877,0.0001920829,0.0004799528,0.0004038939,0.0004804681,0.0004558705],"domain_scores_gemma":[0.9986915,0.0002275747,0.0002139184,0.0004924706,0.0001925311,0.0001820348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009316794,0.000137566,0.1237178,0.0002627039,0.00009687386,0.00002887556,0.002184733,0.0001106641,0.8595551,0.00002369521,0.0003268606,0.004238409],"study_design_scores_gemma":[0.009234671,0.01670959,0.354129,0.006294576,0.0003722215,0.0000744813,0.004021139,0.0006293719,0.6032173,0.0004888172,0.003958605,0.0008702112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945993,0.002356037,0.0002479155,0.0005357053,0.0003172321,0.00107045,0.00003709895,0.00003101459,0.0008051895],"genre_scores_gemma":[0.9928543,0.0002365927,0.0006275879,0.0004418468,0.000110084,0.0002237689,0.000004804835,0.00005154352,0.005449492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2563378,"threshold_uncertainty_score":0.7146436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01890761537577933,"score_gpt":0.322110409239435,"score_spread":0.3032027938636556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}