{"id":"W2986188404","doi":"10.1182/blood-2019-129497","title":"No Impact of Donor's Age-Related Clonal Hematopoiesis (ARCH) Observed on Graft-Versus-Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation: Result from Bar-Coded Error Corrected Sequencing in 33 Gene Mutations on 372 Pairs of Donor and Recipient","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Transplantation; Hematopoietic stem cell transplantation; Graft-versus-host disease; Oncology; Stem cell; Deep sequencing; Medicine; Internal medicine; Immunology; Biology; Gene; Genetics; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003391309,0.0001660082,0.0002356035,0.0002584097,0.0001754022,0.0002804475,0.000140569,0.000166605,0.001174605],"category_scores_gemma":[0.0004558242,0.00009685423,0.0001988933,0.0001643899,0.0001887267,0.00008993034,0.0001785098,0.0002194184,0.0001710764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001315436,"about_ca_system_score_gemma":0.0001669201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004157967,"about_ca_topic_score_gemma":0.0005432672,"domain_scores_codex":[0.9996916,0.00005661404,0.00002837542,0.00009157496,0.00009485988,0.00003697162],"domain_scores_gemma":[0.9996556,0.0001018092,0.00008971799,0.00005607826,0.00004504511,0.00005172423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003742163,0.0003745641,0.7279267,0.0001490927,0.0002156267,0.002277129,0.0004542438,0.0004708192,0.2347948,0.0001405654,0.0002324589,0.02922177],"study_design_scores_gemma":[0.00004660566,0.002485298,0.8852574,0.00001955572,0.0003711097,0.008101759,0.0002207876,0.001236679,0.1002027,0.0001328205,0.001907501,0.00001790676],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994091,0.0001263581,0.0001694826,0.000004792516,0.000002304493,0.000004849463,0.00008789139,0.00000278636,0.0001924918],"genre_scores_gemma":[0.9994266,0.00005279053,0.0001604065,0.00001095933,0.000002036807,0.000003569089,0.0002450542,0.000002312371,0.00009633009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001174605,"threshold_uncertainty_score":0.003929436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01749935769278273,"score_gpt":0.2385263630728674,"score_spread":0.2210270053800847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}