{"id":"W2986196170","doi":"10.1182/blood-2019-123742","title":"Mosunetuzumab Induces Complete Remissions in Poor Prognosis Non-Hodgkin Lymphoma Patients, Including Those Who Are Resistant to or Relapsing After Chimeric Antigen Receptor T-Cell (CAR-T) Therapies, and Is Active in Treatment through Multiple Lines","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":182,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada); Spinal Cord Injury BC; University of British Columbia; Jewish General Hospital","funders":"","keywords":"Medicine; Tolerability; Internal medicine; Follicular lymphoma; Lymphoma; Gastroenterology; Rituximab; Dosing; Oncology; Immunology; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002056695,0.0004077179,0.0008081928,0.0003593662,0.0001205242,0.00005954915,0.0001593995,0.0001947828,0.0004355585],"category_scores_gemma":[0.0001213636,0.0003020106,0.00010352,0.000901652,0.00006526944,0.0001902522,0.0001969119,0.0002284094,0.00002359019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005010746,"about_ca_system_score_gemma":0.0002395374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001600149,"about_ca_topic_score_gemma":0.0008031114,"domain_scores_codex":[0.9974005,0.0001940966,0.000529598,0.0007965088,0.0004660533,0.0006132277],"domain_scores_gemma":[0.9987523,0.0002926649,0.0001711856,0.0004427559,0.0001330094,0.0002080654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007063627,0.003025553,0.5305826,0.0001500349,0.000204777,0.00007509126,0.02112888,0.000001414436,0.4121666,3.590228e-7,0.0001460276,0.02545502],"study_design_scores_gemma":[0.03034968,0.004154455,0.6605564,0.004099938,0.0001094242,0.00001020423,0.005086407,0.0001614579,0.2837371,0.00001457399,0.01105743,0.000662891],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939201,0.001703456,0.000001342639,0.0006922528,0.00008830403,0.003036242,0.0001384558,0.00003869119,0.0003811865],"genre_scores_gemma":[0.9925171,0.002542495,0.002632617,0.0003233291,0.00008934543,0.0003805561,0.00005412226,0.00009299454,0.001367472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1299738,"threshold_uncertainty_score":0.9999432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04627110153982159,"score_gpt":0.3115243581487076,"score_spread":0.265253256608886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}