{"id":"W2986196170","doi":"10.1182/blood-2019-123742","title":"Mosunetuzumab Induces Complete Remissions in Poor Prognosis Non-Hodgkin Lymphoma Patients, Including Those Who Are Resistant to or Relapsing After Chimeric Antigen Receptor T-Cell (CAR-T) Therapies, and Is Active in Treatment through Multiple Lines","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":182,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada); Spinal Cord Injury BC; University of British Columbia; Jewish General Hospital","funders":"","keywords":"Medicine; Tolerability; Internal medicine; Follicular lymphoma; Lymphoma; Gastroenterology; Rituximab; Dosing; Oncology; Immunology; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001901626,0.0002858966,0.0003726204,0.0001939718,0.0001500908,0.000169805,0.000157693,0.0002298955,0.002075509],"category_scores_gemma":[0.0001536862,0.00009084008,0.0001880962,0.0001235029,0.0001342594,0.0001538589,0.0001180958,0.0008054924,0.0004503699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002117408,"about_ca_system_score_gemma":0.0001729165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003557127,"about_ca_topic_score_gemma":0.001911248,"domain_scores_codex":[0.9999393,0.000014174,0.000003838206,0.000009621783,0.00001157717,0.00002155026],"domain_scores_gemma":[0.999916,0.00001413292,0.00002059314,0.000008766589,0.000004442949,0.00003608661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.02819557,0.01055767,0.009711547,0.000793003,0.0003869426,0.0005187342,0.0001940202,0.001570002,0.4627763,0.0003364399,0.008796498,0.4761632],"study_design_scores_gemma":[0.05843909,0.3257422,0.3480756,0.0002290998,0.0006487277,0.005843516,0.0002081621,0.005685899,0.1979685,0.000710342,0.05639275,0.00005607241],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925492,0.002860769,0.0006396167,0.0001287957,0.00003562747,0.0002046627,0.0004023093,0.0002106865,0.002968303],"genre_scores_gemma":[0.9975968,0.0006863993,0.0002690656,0.00009639905,0.00002267343,0.00006394318,0.0004381195,0.000008357753,0.0008182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002075509,"threshold_uncertainty_score":0.006943345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04627110153982159,"score_gpt":0.3115243581487076,"score_spread":0.265253256608886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}