{"id":"W2986211227","doi":"10.1182/blood-2019-127119","title":"MANIFEST, a Phase 2 Study of CPI-0610, a Bromodomain and Extraterminal Domain Inhibitor (BETi), As Monotherapy or \"Add-on\" to Ruxolitinib, in Patients with Refractory or Intolerant Advanced Myelofibrosis","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McMaster University; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Ruxolitinib; Myelofibrosis; Bromodomain; Medicine; Internal medicine; Refractory (planetary science); Phases of clinical research; Oncology; Pharmacology; Clinical trial; Chemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001363462,0.001660169,0.001560466,0.0005397139,0.000420258,0.001333775,0.001162413,0.001630401,0.009175902],"category_scores_gemma":[0.000843801,0.0007389057,0.001474332,0.0003975703,0.001101723,0.001281059,0.0005072104,0.004978389,0.002143748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000966246,"about_ca_system_score_gemma":0.0016793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006705655,"about_ca_topic_score_gemma":0.002266298,"domain_scores_codex":[0.9996753,0.0001076827,0.00001685967,0.00007373419,0.00004483787,0.00008172839],"domain_scores_gemma":[0.9993815,0.00007035027,0.0001160947,0.00004984938,0.00005343959,0.0003287331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6050326,0.1318897,0.007599602,0.002199114,0.001661679,0.0006422621,0.0004822334,0.002864206,0.09570999,0.000920928,0.01430929,0.1366884],"study_design_scores_gemma":[0.57566,0.4017248,0.009129359,0.00006932614,0.0005796928,0.0007761632,0.00008836643,0.0008275821,0.00457883,0.0003476424,0.006173,0.00004526644],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9715607,0.004369892,0.001517893,0.001540403,0.0003763282,0.007775124,0.006086441,0.0003688569,0.006404294],"genre_scores_gemma":[0.9608029,0.004007312,0.00517126,0.003444753,0.0003649414,0.007907943,0.009215564,0.000105023,0.008980272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009175902,"threshold_uncertainty_score":0.03069645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01033386244703578,"score_gpt":0.2845839353661351,"score_spread":0.2742500729190993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}