{"id":"W2986211227","doi":"10.1182/blood-2019-127119","title":"MANIFEST, a Phase 2 Study of CPI-0610, a Bromodomain and Extraterminal Domain Inhibitor (BETi), As Monotherapy or \"Add-on\" to Ruxolitinib, in Patients with Refractory or Intolerant Advanced Myelofibrosis","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McMaster University; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Ruxolitinib; Myelofibrosis; Bromodomain; Medicine; Internal medicine; Refractory (planetary science); Phases of clinical research; Oncology; Pharmacology; Clinical trial; Chemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001502165,0.0003920493,0.0007978619,0.000254909,0.00005339209,0.00002674404,0.00008816874,0.00008988313,0.000384196],"category_scores_gemma":[0.00003947608,0.000238541,0.00004818754,0.0002856694,0.00004381477,0.0001150478,0.00003923997,0.0001687268,0.00003605594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008156541,"about_ca_system_score_gemma":0.0001524249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001120032,"about_ca_topic_score_gemma":0.000338889,"domain_scores_codex":[0.9977884,0.0001354288,0.0005438631,0.0006584668,0.0005055211,0.0003682794],"domain_scores_gemma":[0.9987949,0.0001996514,0.000183931,0.0004478343,0.0001117404,0.0002619823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.06468765,0.05450607,0.8572944,0.0001930372,0.0004227664,0.0007742458,0.007118153,0.000004831001,0.005351648,0.00003766789,0.00004664872,0.009562864],"study_design_scores_gemma":[0.1498813,0.1278122,0.7029257,0.00115546,0.0001951462,0.00005919961,0.001865016,0.000003952822,0.01529149,0.00001661517,0.0003911406,0.0004027608],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954991,0.00004452343,0.000002311204,0.00009765635,0.00004965756,0.003959441,0.00005973891,0.00002247366,0.0002650947],"genre_scores_gemma":[0.997115,0.0000240974,0.001557344,0.0003355629,0.00005275799,0.00051645,0.00002178135,0.00005519166,0.0003218155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1543687,"threshold_uncertainty_score":0.9727419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01033386244703578,"score_gpt":0.2845839353661351,"score_spread":0.2742500729190993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}