{"id":"W2986245988","doi":"10.3390/cancers11111698","title":"Next-Generation Multimodality of Nanomedicine Therapy: Size and Structure Dependence of Folic Acid Conjugated Copolymers Actively Target Cancer Cells in Disabling Cell Division and Inducing Apoptosis","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Military College of Canada; Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Queen's University","keywords":"Folate receptor; Intracellular; Copolymer; Internalization; Apoptosis; Chemistry; Cancer cell; Biophysics; Conjugated system; Cancer research; Cell; Biochemistry; Cancer; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002614862,0.0001564395,0.0003449914,0.000072554,0.00004402667,0.00002187946,0.0001105044,0.00008752553,0.0002081222],"category_scores_gemma":[0.00003904503,0.0001368791,0.00002055508,0.00023259,0.0001944653,0.0003649361,0.00004991171,0.00009929354,6.922615e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002651125,"about_ca_system_score_gemma":0.0002687804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005373544,"about_ca_topic_score_gemma":0.0001705634,"domain_scores_codex":[0.9987237,0.0001062198,0.0003310743,0.000371853,0.0002409322,0.0002262281],"domain_scores_gemma":[0.9992383,0.0001456654,0.0002744186,0.0001816083,0.00008197119,0.00007808136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001608709,0.00001345112,0.014385,0.0000994853,0.000007566123,3.176019e-7,0.001648314,0.004950143,0.9776624,0.00000248335,0.000004643673,0.001065304],"study_design_scores_gemma":[0.001649919,0.0001117754,0.004670167,0.0001187179,0.00001193723,1.958135e-7,0.000587409,0.006119546,0.9865776,0.00001333168,0.000002675503,0.0001367399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974835,0.001582892,0.00003989779,0.00003820899,0.0003308459,0.0003790301,0.0001264797,0.00001090376,0.000008274704],"genre_scores_gemma":[0.9990075,0.0003943999,0.0004534437,0.00008294477,0.00002594082,0.00001098979,0.000004601301,0.00001431691,0.000005924572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009714832,"threshold_uncertainty_score":0.8123226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01977543271854786,"score_gpt":0.2529968923688331,"score_spread":0.2332214596502852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}