{"id":"W2986279507","doi":"10.1016/s1474-4422(19)30354-0","title":"Serum neurofilament light chain in genetic frontotemporal dementia: a longitudinal, multicentre cohort study","year":2019,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":186,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Western University; University of Toronto; Sunnybrook Hospital; Occupational Cancer Research Centre; Université Laval","funders":"Medical Research Council; Stockholm läns landsting; Stichting Dioraphte; Hjärnfonden; Vetenskapsrådet; Ministero della Salute; Alzheimer’s Research UK; European Commission; ZonMw; Fondation Thierry Latran; Ionis Pharmaceuticals; Wellcome Trust; Deutsche Forschungsgemeinschaft; Alzheimerfonden; Fundació la Marató de TV3; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Alzheimer Society; Karolinska Institutet; EU Joint Programme – Neurodegenerative Disease Research; AbbVie","keywords":"Frontotemporal dementia; C9orf72; Medicine; Dementia; Cohort; Oncology; Genetic testing; Frontotemporal lobar degeneration; Internal medicine; Cohort study; Pediatrics; Psychiatry; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005354888,0.0002080308,0.0006258339,0.00009593254,0.00005581852,0.00002226792,0.000379479,0.00009368679,0.0006609613],"category_scores_gemma":[0.00004828394,0.0001353379,0.00006277706,0.00021554,0.00006609767,0.0000431777,0.0003102557,0.0006945991,0.0004354903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004588079,"about_ca_system_score_gemma":0.00004532783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004320545,"about_ca_topic_score_gemma":0.0005213119,"domain_scores_codex":[0.9973182,0.0005859329,0.0003537507,0.0005663873,0.0004416852,0.0007340543],"domain_scores_gemma":[0.9987757,0.00009144437,0.00008788327,0.0008930842,0.00004419168,0.0001077573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009769859,0.000405164,0.9947072,0.00002518604,0.0001248297,0.0004969917,0.0003332518,0.0001151682,0.001715796,0.00001009537,0.0008128032,0.0002764804],"study_design_scores_gemma":[0.004552457,0.001585267,0.9899266,0.00001159399,0.00007413928,0.00005478743,0.00003440277,0.002189819,0.0000223861,0.00002022108,0.00142202,0.0001062544],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698638,0.000234304,0.000003900027,0.02616853,0.0003057908,0.00281226,0.000002619415,0.0000531022,0.0005557244],"genre_scores_gemma":[0.9958816,0.0001193505,0.00003471607,0.003119704,0.0002834157,0.0001113271,0.000003754867,0.00003477815,0.0004114141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02601777,"threshold_uncertainty_score":0.7237062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02919231999539807,"score_gpt":0.2940176504076115,"score_spread":0.2648253304122135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}