{"id":"W2986399619","doi":"10.7554/elife.24278.021","title":"Author response: Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion","year":2017,"lang":"en","type":"peer-review","venue":"","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Synaptobrevin; Synaptic vesicle; Lipid bilayer fusion; Vesicle fusion; Neurotransmitter; SNAP25; Cell biology; Caenorhabditis elegans; Biology; Chemistry; Vesicle; Biochemistry; Membrane; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001337606,0.0004642938,0.0005660108,0.0005058048,0.0007083464,0.001597761,0.0006897611,0.001886709,0.1992068],"category_scores_gemma":[0.008069064,0.0002270011,0.0002549984,0.000301895,0.0008280306,0.000708064,0.001298193,0.00160332,0.08380137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009083166,"about_ca_system_score_gemma":0.001484669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001230552,"about_ca_topic_score_gemma":0.003279102,"domain_scores_codex":[0.9989724,0.0001259414,0.00006627704,0.0001661563,0.0004907278,0.000178393],"domain_scores_gemma":[0.9947891,0.00106757,0.000287238,0.0003115867,0.002692835,0.0008516954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001399214,0.00008897887,0.002561397,0.0009992678,0.00005767134,0.001421608,0.0004310993,0.0007275762,0.09877115,0.005573766,0.8210028,0.06696549],"study_design_scores_gemma":[0.00009791194,0.0001245778,0.006806436,0.000105559,0.0000267814,0.0007390179,0.0007545178,0.001032289,0.04911329,0.001850632,0.9393034,0.00004559821],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.130005,0.012936,0.01603007,0.2734674,0.2408416,0.0007811168,0.007412758,0.005926735,0.3125994],"genre_scores_gemma":[0.1511938,0.00395353,0.002966867,0.01450845,0.006679362,0.0001047388,0.003568111,0.001266508,0.8157587],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.1992068,"threshold_uncertainty_score":0.6664131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0240887649268314,"score_gpt":0.2855853070748522,"score_spread":0.2614965421480208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}