{"id":"W2986416002","doi":"10.1016/j.celrep.2019.09.087","title":"NFE2L3 Controls Colon Cancer Cell Growth through Regulation of DUX4, a CDK1 Inhibitor","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University","funders":"Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Genome Canada; Cancer Research Society; Fonds De La Recherche Scientifique - FNRS; McGill University; Nationwide Children's Hospital; Université Catholique de Louvain","keywords":"Cyclin-dependent kinase 1; CDK inhibitor; Cancer research; Cyclin-dependent kinase; Cell growth; Cell cycle; Transcription factor; Gene silencing; Biology; Gene knockdown; Colorectal cancer; Kinase; Cell biology; Cancer; Cell culture; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001733001,0.0001395984,0.0002022702,0.00001362298,0.00003234109,0.00001105218,0.00006921373,0.0001861072,0.0002545437],"category_scores_gemma":[0.00002949952,0.0001324492,0.0001052961,0.00005205376,0.00003948797,0.000007710747,0.00006056351,0.00006222382,0.00001224686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002236693,"about_ca_system_score_gemma":0.0001289615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001881453,"about_ca_topic_score_gemma":0.0000246617,"domain_scores_codex":[0.9989073,0.00004111827,0.0003440315,0.0003532908,0.0001587497,0.0001954803],"domain_scores_gemma":[0.9990106,0.00001077299,0.0003774556,0.0003901272,0.0001597646,0.00005124164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006459305,0.00006774398,0.007645415,0.0001191156,0.00001355658,0.00001009288,0.00009126127,0.00002668051,0.9897151,0.00002912923,0.002095113,0.0001221986],"study_design_scores_gemma":[0.0004810613,0.0002310883,0.001087496,0.00002683542,0.00001953801,0.00001750151,0.00003329231,0.00001388866,0.9701218,0.0002271066,0.0275859,0.0001544602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9550014,0.001839878,0.0001059494,0.00003617781,0.0004318945,0.0005005496,0.00001380037,0.00001295111,0.04205744],"genre_scores_gemma":[0.993567,0.0002028874,0.0002613977,0.0001302475,0.0002298531,0.00004741186,0.00009058832,0.00002422355,0.005446354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03856568,"threshold_uncertainty_score":0.5401121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007797934932942708,"score_gpt":0.2276696999739375,"score_spread":0.2198717650409948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}