{"id":"W2986416002","doi":"10.1016/j.celrep.2019.09.087","title":"NFE2L3 Controls Colon Cancer Cell Growth through Regulation of DUX4, a CDK1 Inhibitor","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University","funders":"Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Genome Canada; Cancer Research Society; Fonds De La Recherche Scientifique - FNRS; McGill University; Nationwide Children's Hospital; Université Catholique de Louvain","keywords":"Cyclin-dependent kinase 1; CDK inhibitor; Cancer research; Cyclin-dependent kinase; Cell growth; Cell cycle; Transcription factor; Gene silencing; Biology; Gene knockdown; Colorectal cancer; Kinase; Cell biology; Cancer; Cell culture; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008841363,0.0002303769,0.0001493293,0.0002000306,0.0002122528,0.0003023423,0.0001291277,0.0001589363,0.0009709427],"category_scores_gemma":[0.00007481975,0.00009331503,0.0001674931,0.0001214174,0.0002660582,0.0001326657,0.0001579835,0.0003062913,0.0002265521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006423257,"about_ca_system_score_gemma":0.0002860162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002095226,"about_ca_topic_score_gemma":0.003603264,"domain_scores_codex":[0.9999142,0.00001298881,0.000006079386,0.00002089236,0.00002129049,0.00002447146],"domain_scores_gemma":[0.999951,0.000005107032,0.00001604146,0.000005186971,0.000006571269,0.00001609463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001642591,0.00001714505,0.0004698403,0.00002178125,0.000003623802,0.0000380162,0.00001482963,0.0000529529,0.9978184,0.0001420801,0.0000853025,0.001171855],"study_design_scores_gemma":[0.00002885147,0.00008459644,0.006379727,0.000003040018,0.000007633317,0.0001323242,0.00003665523,0.001032324,0.9876397,0.00006287586,0.004588003,0.00000415493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991354,0.00263234,0.002502377,0.0002044428,0.00004617501,0.00001408957,0.0006919528,0.0002204728,0.002334062],"genre_scores_gemma":[0.9964832,0.0004145785,0.0007065355,0.00003714438,0.000003648137,0.00001518426,0.0002471209,0.00002161088,0.002070982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002095226,"threshold_uncertainty_score":0.004660428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007797934932942708,"score_gpt":0.2276696999739375,"score_spread":0.2198717650409948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}