{"id":"W2986543717","doi":"10.1101/829689","title":"A small molecule antagonist for the Tudor domain of SMN disrupts the interaction between SMN and RNAP II","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; Western Economic Diversification Canada; Canadian Institutes of Health Research; Biological and Environmental Research; National Natural Science Foundation of China; Novartis Pharma; Ontario Genomics Institute; National Research Council Canada; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Ministry of Research, Innovation and Science; Ontario Genomics; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Pfizer; University of Saskatchewan; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source; University of Chicago; Argonne National Laboratory; U.S. Department of Energy","keywords":"Spinal muscular atrophy; Biology; Cell biology; Cas9; Antagonist; CRISPR; Chemistry; Genetics; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001181812,0.0002757201,0.0002496906,0.0001129484,0.0001153388,0.0001274375,0.0002484925,0.0002183009,0.00171988],"category_scores_gemma":[0.00005768745,0.00008103615,0.0001254238,0.00004703561,0.0001418474,0.00007251042,0.00009553983,0.0003168761,0.0003330155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001978325,"about_ca_system_score_gemma":0.000193953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000421003,"about_ca_topic_score_gemma":0.0008391924,"domain_scores_codex":[0.9999468,0.000009858038,0.00000324025,0.000009156563,0.00001436107,0.00001664162],"domain_scores_gemma":[0.9999781,0.000004535208,0.000005899467,0.000001804895,0.00000216323,0.000007662925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001263102,0.00004115788,0.00007482419,0.0000228748,0.000008650814,0.00004499526,0.000004805531,0.0001187287,0.9981866,0.0001974593,0.0001050347,0.001068561],"study_design_scores_gemma":[0.00004778526,0.0004780694,0.0005128484,0.000003036274,0.00001028683,0.0001259291,0.000005842092,0.000810701,0.9951521,0.00002208514,0.002828555,0.000002670759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907557,0.001556037,0.003667118,0.0001860063,0.00006136559,0.00006139012,0.0003621425,0.0000791128,0.003271081],"genre_scores_gemma":[0.9904174,0.000685695,0.003252547,0.00007863305,0.00001811241,0.00003742951,0.0004651172,0.00001387899,0.005031212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00171988,"threshold_uncertainty_score":0.005753636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03089467472460591,"score_gpt":0.2801180821522116,"score_spread":0.2492234074276057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}