{"id":"W2986559221","doi":"10.1016/j.semcdb.2019.10.016","title":"A centralized communication network: Recent insights into the role of the cancer associated fibroblast in the development of drug resistance in tumors","year":2019,"lang":"en","type":"review","venue":"Seminars in Cell and Developmental Biology","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Cancer Research Society","keywords":"Cancer research; Cancer-Associated Fibroblasts; Tumor microenvironment; Matricellular protein; Extracellular matrix; Vasculogenic mimicry; Cancer; Angiogenesis; Biology; Medicine; Immunology; Metastasis; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009820915,0.0002413757,0.0005993677,0.00008454565,0.00008074298,0.000007458006,0.0008732384,0.0002433585,0.00001043496],"category_scores_gemma":[0.000128542,0.0001338211,0.00006957684,0.0005477219,0.0002508909,0.000003335385,0.0006860208,0.0003834513,0.000001009273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000245752,"about_ca_system_score_gemma":0.0007912909,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002257954,"about_ca_topic_score_gemma":0.02001643,"domain_scores_codex":[0.9972989,0.001158872,0.0007348656,0.0003594203,0.000132963,0.0003149788],"domain_scores_gemma":[0.9988587,0.0003349521,0.0003769725,0.0003595441,0.00004919454,0.00002062092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004974761,0.0006675966,0.09885996,0.004842155,0.0003527752,0.00000460382,0.06360751,0.00001586966,0.01866507,0.0003302355,0.0009068054,0.81125],"study_design_scores_gemma":[0.0007160447,0.00003853517,0.007795404,0.008683491,0.00002457248,0.000002225141,0.002828383,0.000002405275,0.01085026,0.0003904957,0.9683072,0.0003609722],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2236027,0.774969,3.305657e-7,0.00004247547,0.00003584581,0.0008067834,0.000008634467,0.000001041146,0.000533226],"genre_scores_gemma":[0.1467934,0.8524511,0.0002362451,0.0000205201,0.000007511375,0.0001803938,0.0001667402,0.00001401753,0.0001300604],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9674004,"threshold_uncertainty_score":0.9978657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02247513514584504,"score_gpt":0.3071260458445614,"score_spread":0.2846509106987164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}