{"id":"W2986559985","doi":"10.1016/j.bbapap.2019.140318","title":"Rat cathepsin K: Enzymatic specificity and regulation of its collagenolytic activity","year":2019,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Conseil Régional du Centre-Val de Loire; Université François-Rabelais; University of British Columbia; Narodowe Centrum Nauki; Institut National de la Santé et de la Recherche Médicale; Uniwersytet Gdański; Centre National de la Recherche Scientifique; Narodowym Centrum Nauki; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation","keywords":"Cathepsin K; Chemistry; Cathepsin; Kininogen; N-terminal telopeptide; Biochemistry; Collagenase; Bone resorption; Enzyme; Molecular biology; Biology; Osteoclast; Endocrinology; Alkaline phosphatase; In vitro; Kallikrein","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003239831,0.000391848,0.000348008,0.0005027659,0.0001693675,0.0005737137,0.0002840642,0.0003192684,0.0009753346],"category_scores_gemma":[0.0004387111,0.0002778669,0.0004374345,0.0003269223,0.0003340922,0.0003345936,0.0002249131,0.000363165,0.0004072275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005950406,"about_ca_system_score_gemma":0.0003092088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001532635,"about_ca_topic_score_gemma":0.001367822,"domain_scores_codex":[0.9997365,0.00004792928,0.00003688158,0.00006415664,0.00003765971,0.00007694526],"domain_scores_gemma":[0.9996407,0.00007816483,0.00008784304,0.00005324343,0.00005802649,0.00008196309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001168853,0.00002530853,0.001567204,0.00005476473,0.00001936617,0.0001079857,0.00002827401,0.00009793202,0.9937857,0.0001571606,0.0000342573,0.002953226],"study_design_scores_gemma":[0.00002437817,0.0002503914,0.02779087,0.000007626292,0.00004908178,0.001318869,0.00005116519,0.0007741426,0.9683335,0.0001108727,0.001275033,0.00001418333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891846,0.006922639,0.002701624,0.00009758939,0.00002086465,0.00001121027,0.0002673173,0.00004546203,0.0007486478],"genre_scores_gemma":[0.9957346,0.00149772,0.001165926,0.00002415473,0.00001216288,0.00000905741,0.0003806845,0.00001841409,0.001157288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001532635,"threshold_uncertainty_score":0.004317284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008469614902830486,"score_gpt":0.2232608978520353,"score_spread":0.2147912829492048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}