{"id":"W2986567088","doi":"10.1182/blood-2019-126035","title":"Pioneer: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of Avapritinib in Patients with Indolent or Smoldering Systemic Mastocytosis with Symptoms Inadequately Controlled with Standard Therapy","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Medicine; Systemic mastocytosis; Tolerability; Adverse effect; Internal medicine; Mast cell; Mucositis; Cutaneous Mastocytosis; Neutropenia; Gastroenterology; Oncology; Pharmacology; Immunology; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007681184,0.0005065844,0.002893825,0.0003746689,0.0001013906,0.00003524096,0.0002457915,0.0001883357,0.0003220771],"category_scores_gemma":[0.00001950495,0.0002643791,0.0001283272,0.0002939492,0.0001725104,0.0001134433,0.00004575418,0.0003650481,0.00001841043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006554084,"about_ca_system_score_gemma":0.0001967403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002690226,"about_ca_topic_score_gemma":0.0002875018,"domain_scores_codex":[0.997173,0.0005019925,0.001000366,0.0005695596,0.0002434225,0.0005116566],"domain_scores_gemma":[0.9980185,0.0004081902,0.0007440242,0.0005026865,0.0002762033,0.00005036873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9418474,0.007841376,0.04176751,0.0001084453,0.003855063,0.00002958605,0.00269283,0.0001719065,0.001324104,0.00003348582,0.00000240859,0.000325838],"study_design_scores_gemma":[0.9705075,0.02351777,0.000432173,0.0005294391,0.0007954171,0.00003863146,0.001501909,0.000008179056,0.002245137,5.368688e-7,0.00003339017,0.0003898858],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821428,0.0009183411,0.0000747447,0.00001398443,0.0001019262,0.01634326,0.00003779123,0.00005121348,0.0003159065],"genre_scores_gemma":[0.9974107,0.00004341325,0.00003654182,0.00002057043,0.00001306563,0.00173415,0.00005322,0.00006044152,0.0006278813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04133534,"threshold_uncertainty_score":0.9999809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01087479946830518,"score_gpt":0.230279191628839,"score_spread":0.2194043921605338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}