{"id":"W2986567088","doi":"10.1182/blood-2019-126035","title":"Pioneer: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of Avapritinib in Patients with Indolent or Smoldering Systemic Mastocytosis with Symptoms Inadequately Controlled with Standard Therapy","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Medicine; Systemic mastocytosis; Tolerability; Adverse effect; Internal medicine; Mast cell; Mucositis; Cutaneous Mastocytosis; Neutropenia; Gastroenterology; Oncology; Pharmacology; Immunology; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001700445,0.00175586,0.003132895,0.0005016407,0.0004545147,0.001083945,0.001215143,0.002167923,0.01013883],"category_scores_gemma":[0.001292766,0.0006561117,0.001878652,0.0003721047,0.0009964971,0.001324091,0.0003624897,0.002791617,0.001614118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007282509,"about_ca_system_score_gemma":0.001380393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007231575,"about_ca_topic_score_gemma":0.002036647,"domain_scores_codex":[0.9995143,0.0002129813,0.00002374475,0.0001100122,0.00005577381,0.000083153],"domain_scores_gemma":[0.9994321,0.0001294662,0.0001374544,0.00005146087,0.00006035154,0.0001890195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9501495,0.009937454,0.0006588353,0.001993387,0.001667283,0.0001026017,0.00006921131,0.0005699727,0.009510268,0.000248212,0.002971626,0.02212161],"study_design_scores_gemma":[0.9598571,0.0374476,0.0009388222,0.0000237841,0.0002403072,0.00004229713,0.000009387612,0.0002302234,0.0002188205,0.00008226472,0.0008985046,0.00001093824],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9469754,0.01829447,0.002316964,0.00167688,0.001696232,0.0162656,0.00499277,0.0008957042,0.006886005],"genre_scores_gemma":[0.9560835,0.006945261,0.004716572,0.002741438,0.0009788127,0.01591831,0.003786981,0.00008829972,0.008740757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01013883,"threshold_uncertainty_score":0.03391778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01087479946830518,"score_gpt":0.230279191628839,"score_spread":0.2194043921605338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}