{"id":"W2986598134","doi":"10.1093/neuonc/noz175.798","title":"PDTM-22. A C19MC-LIN28A-MYCN ONCOGENIC CIRCUIT DRIVEN BY HIJACKED SUPER-ENHANCERS IS A DISTINCT THERAPEUTIC VULNERABILITY IN ETMRS – A LETHAL BRAIN TUMOR","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Cancer research; Biology; Enhancer; Embryonic stem cell; Neural stem cell; Chromatin; Lineage (genetic); Cell; Gene; Cell biology; Stem cell; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006317206,0.0001984614,0.00014443,0.0001166383,0.00009923833,0.0001360917,0.0001370539,0.0001688405,0.00137036],"category_scores_gemma":[0.00004906851,0.00006687838,0.0001138914,0.00005745747,0.0001337174,0.00009650381,0.0001163869,0.0004088139,0.0002260946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002024494,"about_ca_system_score_gemma":0.0001197106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003831542,"about_ca_topic_score_gemma":0.0006558279,"domain_scores_codex":[0.9999373,0.000007726646,0.00000415201,0.00001519753,0.00001767929,0.0000179991],"domain_scores_gemma":[0.9999644,0.000007054476,0.000007526141,0.000005435977,0.000002714228,0.00001292334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007419341,0.00002901919,0.000123188,0.00001157164,0.00000358062,0.00004604472,0.000005094837,0.00006992962,0.9984788,0.000151891,0.00003015727,0.0009765864],"study_design_scores_gemma":[0.00001050125,0.0003408732,0.001328881,0.000001183358,0.000006409758,0.0002561585,0.000006831922,0.0006026523,0.9956923,0.00003403124,0.001719045,0.00000122501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960626,0.0005086312,0.001648595,0.00004339754,0.00001396666,0.00002592181,0.0001997508,0.00006056769,0.001436607],"genre_scores_gemma":[0.997103,0.0001848649,0.000800959,0.00001638356,0.000002250662,0.0000174331,0.0002275701,0.000009669225,0.001637773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00137036,"threshold_uncertainty_score":0.004584372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01514678166864293,"score_gpt":0.2805255523321021,"score_spread":0.2653787706634592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}