{"id":"W2986608952","doi":"10.1039/c9md00402e","title":"High affinity rigidified AT<sub>2</sub> receptor ligands with indane scaffolds","year":2019,"lang":"en","type":"article","venue":"MedChemComm","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; Stiftelsen för Strategisk Forskning; Vetenskapsrådet; Stiftelsen för Strategisk Forskning; Alzheimer's Society","keywords":"Indane; Chemistry; Agonist; Stereochemistry; Receptor; Combinatorial chemistry; Side chain; Organic chemistry; Biochemistry; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002996896,0.0002909054,0.0003086392,0.00004835553,0.000128354,0.00004020982,0.0002983148,0.0002942797,0.0004941875],"category_scores_gemma":[0.00002426124,0.0002411163,0.0001141068,0.0001415482,0.00005825285,0.000007366677,0.0002011483,0.000124219,0.0003232075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004268519,"about_ca_system_score_gemma":0.00007422749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001959123,"about_ca_topic_score_gemma":0.00003872847,"domain_scores_codex":[0.998477,0.000046741,0.0002498939,0.0005317194,0.0002761551,0.0004184975],"domain_scores_gemma":[0.9989605,0.00002215205,0.0001353323,0.000612168,0.00009828761,0.0001715395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002486607,0.00006891701,0.001637528,0.0000257016,0.00007238636,0.000002842052,0.00005541356,0.00003588517,0.9937693,0.000133156,0.002761833,0.001188301],"study_design_scores_gemma":[0.001104492,0.0005468242,0.0003107434,0.00003555424,0.00002054104,0.00001463867,0.0000571407,0.00001287912,0.9834874,0.00004504693,0.013995,0.0003697233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976737,0.000205374,0.0002261144,0.0001573422,0.0004241726,0.0002671122,0.000020927,0.00004394918,0.0009813065],"genre_scores_gemma":[0.9965537,0.0001119756,0.001026715,0.0003168616,0.0003225851,0.00003249611,0.0003116041,0.00005999356,0.001264113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01123316,"threshold_uncertainty_score":0.9832435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004533298004989204,"score_gpt":0.185417161003706,"score_spread":0.1808838629987168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}