{"id":"W2986608952","doi":"10.1039/c9md00402e","title":"High affinity rigidified AT<sub>2</sub> receptor ligands with indane scaffolds","year":2019,"lang":"en","type":"article","venue":"MedChemComm","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; Stiftelsen för Strategisk Forskning; Vetenskapsrådet; Stiftelsen för Strategisk Forskning; Alzheimer's Society","keywords":"Indane; Chemistry; Agonist; Stereochemistry; Receptor; Combinatorial chemistry; Side chain; Organic chemistry; Biochemistry; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001082937,0.0003579695,0.0001884717,0.0001120342,0.0001282579,0.0002239196,0.0002764529,0.0002963685,0.002986571],"category_scores_gemma":[0.0001051117,0.0001505815,0.0001775069,0.0001023676,0.0001782358,0.0003096932,0.0002671606,0.0006458813,0.001096123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002582895,"about_ca_system_score_gemma":0.0001580979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00026744,"about_ca_topic_score_gemma":0.000665926,"domain_scores_codex":[0.9999263,0.00001002486,0.000003481385,0.00001560144,0.00001817864,0.00002633232],"domain_scores_gemma":[0.9999479,0.00000736489,0.00001928103,0.000007463932,0.000005773513,0.00001221798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009347589,0.00002533074,0.00003499541,0.00002990197,0.000004613044,0.00005665967,0.00002079844,0.0003291814,0.9967061,0.0005640902,0.0001342345,0.002000687],"study_design_scores_gemma":[0.00002610872,0.0004502717,0.0006476024,0.000005585724,0.000009723847,0.0001861817,0.00001896684,0.001002506,0.9904204,0.00009368653,0.007123484,0.00001549725],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981548,0.001440705,0.007780229,0.000160812,0.00006865927,0.00006624316,0.0002456294,0.0001862078,0.008503549],"genre_scores_gemma":[0.980359,0.001269977,0.006859416,0.0001749932,0.00002719584,0.00008865033,0.0003837363,0.0000545465,0.01078264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002986571,"threshold_uncertainty_score":0.009991109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004533298004989204,"score_gpt":0.185417161003706,"score_spread":0.1808838629987168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}