{"id":"W2986633517","doi":"10.1016/s0140-6736(19)32591-7","title":"Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study","year":2019,"lang":"en","type":"article","venue":"The Lancet","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":3211,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institute for Health and Care Research; Regeneron Pharmaceuticals; Eisai; Sanofi; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company; GlaxoSmithKline","keywords":"Cetuximab; Pembrolizumab; Medicine; Chemotherapy; Head and neck; Oncology; Open label; Internal medicine; Head and neck squamous-cell carcinoma; Head and neck cancer; Basal cell; Radiation therapy; Randomized controlled trial; Surgery; Cancer; Immunotherapy; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00296597,0.002805903,0.003910603,0.0006129789,0.0005486738,0.0014837,0.001550076,0.002583902,0.01006429],"category_scores_gemma":[0.002400821,0.001165889,0.003797054,0.000647464,0.001737543,0.002127991,0.0006111935,0.004690844,0.001931821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001463265,"about_ca_system_score_gemma":0.00139357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002519119,"about_ca_topic_score_gemma":0.004995063,"domain_scores_codex":[0.9989736,0.0005671051,0.00004940177,0.0001719429,0.00006624962,0.0001717706],"domain_scores_gemma":[0.998902,0.0003855705,0.000249077,0.00009817716,0.00006224282,0.0003028927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9878243,0.003619879,0.0001663895,0.0004197726,0.0008049628,0.00001840592,0.00003172067,0.0001973024,0.001013586,0.00007608109,0.0003990044,0.005428587],"study_design_scores_gemma":[0.955549,0.0427134,0.0006130429,0.00002446614,0.0004120319,0.00001536577,0.00001807695,0.0001340787,0.0001345648,0.0001021235,0.000273161,0.00001066285],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822076,0.005579641,0.0008297098,0.0008745865,0.001067117,0.004392058,0.001779883,0.0001442555,0.003125188],"genre_scores_gemma":[0.9759137,0.00460615,0.002127216,0.001635105,0.0006550559,0.005591313,0.001619713,0.00005180443,0.007799851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01006429,"threshold_uncertainty_score":0.03366834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07298323492845854,"score_gpt":0.3622532573765874,"score_spread":0.2892700224481288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}