{"id":"W2986664629","doi":"10.1182/blood-2019-131595","title":"Arsenic Trioxide Abrogate MN1 Mediated RA-Resistance in Acute Promyelocytic Leukemia","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Arsenic trioxide; Acute promyelocytic leukemia; Medicine; Leukemia; Arsenic; Cancer research; Immunology; Chemistry; Biology; Retinoic acid; Genetics; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000123001,0.0003181639,0.0002962318,0.0003478703,0.0001511527,0.0002033994,0.0001972454,0.0001413445,0.001674552],"category_scores_gemma":[0.00007684757,0.0000896878,0.0002142345,0.0002076978,0.0001337775,0.0001012166,0.0001605674,0.0004392193,0.0004741134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001915852,"about_ca_system_score_gemma":0.0002136367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004880718,"about_ca_topic_score_gemma":0.0009134197,"domain_scores_codex":[0.9998789,0.00002603538,0.00001522607,0.0000162808,0.00003619511,0.00002725262],"domain_scores_gemma":[0.9999366,0.00000857055,0.00001620186,0.00001095037,0.000009777985,0.00001787566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003964117,0.0001429147,0.0003914958,0.00006817218,0.00001335815,0.00008733985,0.00003087955,0.0001198101,0.9947206,0.00008332675,0.000167369,0.003778324],"study_design_scores_gemma":[0.00006898554,0.002328436,0.005417537,0.00001025398,0.00003742543,0.0004738236,0.00004354301,0.0005596568,0.9857695,0.00004899768,0.005237007,0.000004955508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941204,0.002102347,0.0008520788,0.00009105523,0.00004161265,0.00007439413,0.0006416205,0.0001601639,0.001916287],"genre_scores_gemma":[0.9938897,0.001384073,0.0008963506,0.00002702407,0.00001238721,0.00004614163,0.0007777932,0.00001377606,0.002952649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001674552,"threshold_uncertainty_score":0.005601943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00353795090343305,"score_gpt":0.2089278258512849,"score_spread":0.2053898749478519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}