{"id":"W2986774062","doi":"10.1016/j.cell.2019.10.024","title":"Multisystem Toxicity in Cancer: Lessons from NASA’s Countermeasures Program","year":2019,"lang":"en","type":"article","venue":"Cell","topic":"Spaceflight effects on biology","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; National Institutes of Health; Memorial Sloan-Kettering Cancer Center","keywords":"Biology; Spaceflight; Cancer; Cancer therapy; Engineering; Aerospace engineering; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001416071,0.0001372992,0.000364342,0.00006632745,0.00001414493,0.00001055288,0.0001028577,0.0001699136,0.000295572],"category_scores_gemma":[0.00002684671,0.0001098662,0.00005811973,0.0001049491,0.000038592,0.00002850197,0.00003236557,0.0002027945,0.0004264999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001795171,"about_ca_system_score_gemma":0.00009501605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002223466,"about_ca_topic_score_gemma":0.00153514,"domain_scores_codex":[0.999014,0.00007673936,0.0001694356,0.0003214931,0.0001452957,0.0002730393],"domain_scores_gemma":[0.9993678,0.00009647391,0.00006611516,0.0003339757,0.00004701644,0.00008863696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002071931,0.0004462742,0.5983279,0.0002028233,0.00003262508,0.00006197526,0.0003622636,0.000007930946,0.3917832,0.00001096146,0.002177906,0.006378949],"study_design_scores_gemma":[0.005541101,0.0007901124,0.7261142,0.0005483115,0.00005066156,0.00001119066,0.000233324,0.001695782,0.2046261,0.00001384295,0.06007293,0.0003024679],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896829,0.0011923,0.000005342822,0.0007934027,0.0005920604,0.001173311,0.00002630997,0.0001054511,0.006428993],"genre_scores_gemma":[0.9973644,0.00006279511,0.0002428683,0.0003589281,0.0001400186,0.0001248192,0.00002698507,0.00002076499,0.001658419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1871571,"threshold_uncertainty_score":0.5481936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02457628188928416,"score_gpt":0.3289200827483269,"score_spread":0.3043438008590427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}