{"id":"W2986774652","doi":"10.1182/blood-2019-122776","title":"Re-Induction and Targeted Conditioning with Anti-CD45 Iodine (131I) Apamistamab [Iomab-B] Leads to High Rates of Transplantation and Successful Engraftment in Older Patients with Active, Relapsed or Refractory (rel/ref) AML after Failure of Chemotherapy and Targeted Agents: Preliminary Midpoint Results from the Prospective, Randomized Phase 3 Sierra Trial","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Medicine; Venetoclax; Transplantation; Internal medicine; Salvage therapy; Fludarabine; Refractory (planetary science); Oncology; Clinical trial; Surgery; Chemotherapy; Leukemia; Cyclophosphamide; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001269559,0.0004140216,0.0007823775,0.0001584486,0.0001728171,0.0005888899,0.0003853633,0.0003314221,0.001488697],"category_scores_gemma":[0.0007467104,0.0002088074,0.0008145412,0.0001777982,0.0003589255,0.0003203356,0.0002689825,0.001222673,0.0003645332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002966843,"about_ca_system_score_gemma":0.0005110535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003633094,"about_ca_topic_score_gemma":0.001306924,"domain_scores_codex":[0.9996958,0.0001248064,0.00002926779,0.00005766514,0.00004237873,0.0000500439],"domain_scores_gemma":[0.99933,0.000131492,0.0001837448,0.00007049036,0.00002411738,0.0002602415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6343881,0.03221856,0.07611788,0.0006509037,0.001928519,0.0003625896,0.0003258181,0.001891359,0.06752548,0.0002981675,0.006373986,0.1779187],"study_design_scores_gemma":[0.349461,0.431941,0.1937785,0.0001242279,0.002116975,0.001216187,0.0001260841,0.001790949,0.01215051,0.0003404044,0.006895672,0.0000585726],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969645,0.001395794,0.0002092356,0.0001613357,0.00003495635,0.0002468268,0.0003176533,0.00003524204,0.0006344968],"genre_scores_gemma":[0.9955313,0.0009691851,0.0006945209,0.0005047076,0.00008414868,0.0002464113,0.001242007,0.00001224075,0.0007155421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001488697,"threshold_uncertainty_score":0.006714165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006996525404728251,"score_gpt":0.244438449825305,"score_spread":0.2374419244205768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}