{"id":"W2986822804","doi":"10.1182/blood-2019-123655","title":"Luspatercept Significantly Reduces Red Blood Cell (RBC) Transfusion Burden, Regardless of Gene Mutation Frequency, Spectrum, and Prognostic Significance, Among Patients (Pts) with LR-MDS Enrolled in the MEDALIST Trial","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Internal medicine; Population; Bone marrow; Erythropoiesis; Allele frequency; Gastroenterology; Oncology; Anemia; Gene; Allele; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003780559,0.0001580808,0.000312315,0.00009620713,0.00008790335,0.000226849,0.0001187677,0.0001537064,0.001354351],"category_scores_gemma":[0.0005176641,0.00005558261,0.0002010536,0.0001113471,0.0001246139,0.0001437486,0.00009181616,0.0003162246,0.0001372245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001747923,"about_ca_system_score_gemma":0.0001673964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001866592,"about_ca_topic_score_gemma":0.0004213262,"domain_scores_codex":[0.9998956,0.00003694532,0.000009435826,0.00002439949,0.00001694574,0.00001674702],"domain_scores_gemma":[0.99978,0.00005869146,0.00007924862,0.00001229752,0.00001054876,0.00005919857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3721539,0.003488063,0.2598371,0.0005801605,0.001040708,0.0004827142,0.00027041,0.002988758,0.08991342,0.0002980189,0.006962336,0.2619845],"study_design_scores_gemma":[0.02812061,0.1127747,0.8282195,0.00006000932,0.001241283,0.001870802,0.0001208498,0.004753565,0.01479211,0.0003788508,0.007637136,0.00003049064],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998536,0.000565742,0.00006832287,0.0000652546,0.000008465282,0.00002206963,0.000173418,0.00001142756,0.000549355],"genre_scores_gemma":[0.9991593,0.00009309262,0.00008070414,0.00004700061,0.00001675882,0.00001678411,0.0002177159,0.000001608473,0.0003669871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001354351,"threshold_uncertainty_score":0.004530728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008232281644924646,"score_gpt":0.2093162457104168,"score_spread":0.2010839640654921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}