{"id":"W2986822804","doi":"10.1182/blood-2019-123655","title":"Luspatercept Significantly Reduces Red Blood Cell (RBC) Transfusion Burden, Regardless of Gene Mutation Frequency, Spectrum, and Prognostic Significance, Among Patients (Pts) with LR-MDS Enrolled in the MEDALIST Trial","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Internal medicine; Population; Bone marrow; Erythropoiesis; Allele frequency; Gastroenterology; Oncology; Anemia; Gene; Allele; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000333723,0.0002534645,0.0005598501,0.0001783861,0.00006741478,0.00001946168,0.0001325294,0.000178736,0.0001251543],"category_scores_gemma":[0.00006199092,0.0001660667,0.00008520366,0.0003668486,0.000172393,0.00008749763,0.00001196019,0.0002736181,0.000006491695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001799317,"about_ca_system_score_gemma":0.0001149578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005216633,"about_ca_topic_score_gemma":0.0001905715,"domain_scores_codex":[0.9979326,0.0003206346,0.0005375696,0.0005024022,0.0004259266,0.000280853],"domain_scores_gemma":[0.9989712,0.0001893181,0.0002818126,0.0003453927,0.0001255068,0.00008673751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0252854,0.00473791,0.2164893,0.0004901223,0.0002147667,0.0001640262,0.007743539,0.00005510542,0.7442839,0.00002081385,0.00004275344,0.0004723375],"study_design_scores_gemma":[0.2434882,0.02014807,0.4530988,0.0004746531,0.001427257,0.00007707391,0.002743385,0.00008802204,0.2777427,0.0001406605,0.00002623654,0.0005449345],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943879,0.00009429384,0.0000172522,0.0001491027,0.0002133674,0.003163554,0.00002225472,0.00003365818,0.001918652],"genre_scores_gemma":[0.998776,0.0001239437,0.0003093761,0.00006037182,0.000196071,0.0001421508,0.0001500984,0.00003258513,0.0002093803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4665412,"threshold_uncertainty_score":0.6772004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008232281644924646,"score_gpt":0.2093162457104168,"score_spread":0.2010839640654921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}